Dose: 2 to 6 g/day
Single Dose: 4 (4)
Frequency: 6 hourly
Route: PO
Instructions: Initial dose

Dose: 3.5 to 1.5 g/m2
Single Dose: 2.5 (2.5)
Frequency: As recommended.
Route: In divided doses,
Instructions:

. The Molecular Weight of Mitotane is 320.04.

Mitotane is contraindicated in conditions like Hypersensitivity.

Mitotane produces potentially life-threatening effects which include Anemia, Thrombocytopenia, Leucopenia, Anemia. which are responsible for the discontinuation of Mitotane therapy.The signs and symptoms that are produced after the acute overdosage of Mitotane include Blurred vision, Polyneuropathy, Hyperpyrexia, Hypertension, Mycoses, Retinopathy.The symptomatic adverse reactions produced by Mitotane are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Headache, Fatigue, Ataxia, Nausea, Vomiting, Anorexia, Diarrhea, Confusion, Lethargy, Sedation, Depression, Diplopia, Gynecomastia, Epigastric pain, Anemia, Increased bleeding time, Confusion, Sore mouth, dizziness, Ataxia.

'Mitotane is primarily indicated in conditions like Cushing''s syndrome.'

No data regarding the interactions of Mitotane was found.

Decreased level of 17-hydroxy-corticosteroidsDecreased protein-bound iodine levels

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Store Between 15°C-30°C. Protect from Sunlight, Moisture and Heat.

Avoid MITOTANE in severe liver disease Monitor serum concentration of MITOTANE in liver disease Manufacturer advises caution with MITOTANE in liver disease