Methylergonovine

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus.

Brands
Adult Dose
Dose: 1 mL
Single Dose: 1 (1)
Frequency: As recommended.
Route: IV/IM
Instructions: May be repeated as required, at intervals of 2-4 hours.
Neonatal
Paedriatic
Characteristics
Methylergonovine also known as Methylergometrine maleate, Methylergometrine maleate. . It is of Semi Synthetic origin and belongs to Amine alkaloid. . The Molecular Weight of Methylergonovine is 339.43.
Contraindications
Methylergonovine is contraindicated in conditions like Hypertension,Hypersensitivity,Pregnancy,Toxaemia of pregnancy.
Effects
The severe or irreversible adverse effects of Methylergonovine, which give rise to further complications include Hallucinations, Hallucinations, Severe allergic reaction, Blood in the urine.Methylergonovine produces potentially life-threatening effects which include Coma, Seizures. which are responsible for the discontinuation of Methylergonovine therapy.The signs and symptoms that are produced after the acute overdosage of Methylergonovine include Diarrhea, Hematuria, Hallucinations, Palpitations, Tinnitus, Dyspnea, Myocardial infarction.The symptomatic adverse reactions produced by Methylergonovine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Headache, Abdominal pain, Hypotension, Nausea and vomiting, Seizures, dizziness.
Indications
Methylergonovine is primarily indicated in conditions like Postpartum haemorrhage.
Interactions
No data regarding the interactions of Methylergonovine was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tablets Store in a well closed container, Below 30°C. Protect from Sunlight and Heat. Ampules Store Below 15°C. Freezing is recommended. Protect from Sunlight.
Warnings
This drug should not be administered I.V. routinely because of the possibility of inducing sudden hypertensive and cerebrovascular accidents. Caution should be exercised in the presence of sepsis, obliterative vascular disease, hepatic or renal involvement. Also use with caution during the second stage of labor. The necessity for manual removal of a retained placenta should occur only rarely with proper technique and adequate allowance of time for its spontaneous separation.
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