Methocarbamol

'Methocarbamol is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally related to guaifenesin. Methocarbamol''s exact mechanism of causing skeletal muscle relaxation is unknown. It is thought to work centrally, perhaps by general depressant effects. It has no direct relaxant effects on striated muscle, nerve fibers, or the motor endplate. It will not directly relax contracted skeletal muscles. The drug has a secondary sedative effect.'

Brands
Adult Dose
Dose: 500 mg
Single Dose: 500 (500)
Frequency: As recommended.
Route: PO
Instructions: 2 tablets qid
Neonatal
Paedriatic
Characteristics
It belongs to Muscle Relaxants pharmacological group on the basis of mechanism of action. The Molecular Weight of Methocarbamol is 241.24.
Contraindications
Methocarbamol is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The signs and symptoms that are produced after the acute overdosage of Methocarbamol include Hypotension, Coma, Seizures, Blurred vision, Leucopenia.The symptomatic adverse reactions produced by Methocarbamol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Headache, Drowsiness, Fever, Blurred vision, Bradycardia, Jaundice, Dyspepsia, Flushing, Tremor, Hypersensitivity, Nausea and vomiting, Edema, Convulsions, Angioedema, dyspepsia.
Indications
Methocarbamol is primarily indicated in conditions like Painful musculoskeletal conditions.
Interactions
No data regarding the interactions of Methocarbamol was found.
Interfrence
Interference in screening tests for 5-hydroxyindoleacetic acid (5-HIAA) using nitrosonaphthol reagentInterference in screening tests for urinary vanillylmandelic acid (VMA) using the Gitlow method
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store in a well closed container, .
Warnings
Methocarbamol may inhibit the effect of pyridostigmine bromide. Therefore, methocarbamol should be used with caution in patients with myasthenia gravis receiving anticholinesterase agents. Methocarbamol may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. Patients should be cautioned about operating machinery, including automobiles, until they are reasonably certain that methocarbamol therapy does not adversely affect their ability to engage in such activities. Since methocarbamol may possess a general CNS depressant effect, patients receiving ROBAXIN Injectable should be cautioned about combined effects with alcohol and other CNS depressants.
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