Metaxalone

Metaxalone is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Metaxalone does not directly relax tense skeletal muscles in man.

Brands
Adult Dose
Dose: 800 mg
Single Dose: 800 (800)
Frequency: As recommended.
Route: PO
Instructions: 3-4 times a day
Neonatal
Paedriatic
Characteristics
. The Molecular Weight of Metaxalone is 221.25.
Contraindications
Metaxalone is contraindicated in conditions like Anaemia,Impaired hepatic function,Impaired renal function,Hypersensitivity to any component of product.
Effects
The signs and symptoms that are produced after the acute overdosage of Metaxalone include Seizures, Jaundice, Leucopenia, Hemolytic anemia.The symptomatic adverse reactions produced by Metaxalone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Irritability, Nervousness, Nausea and vomiting, Gastrointestinal disturbances, nervousness.
Indications
Metaxalone is primarily indicated in conditions like Painful musculoskeletal conditions.
Interactions
Metaxalone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholOxymorphoneCentral nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.ModerateDuring concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
False +ve Benedicts Test
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tablets Store in a well closed container, at room temperature. Protect from Sunlight, Moisture and Heat.
Warnings
'Metaxalone should be administered with great care to patients with pre-existing liver damage. Serial liver function studies should be performed in these patients. False-positive Benedict''s tests, due to an unknown reducing substance, have been noted. A glucose-specific test will differentiate findings. Taking metaxalone with food may enhance general CNS depression; elderly patients may be especially susceptible to this CNS effect.'
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