Mesoridazine Besylate

Mesoridazine besylate, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer which is effective in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses. Mesoridazine besylate is 10 [2(1-methyl 2-piperidyl) ethyl]-2-(methyl-sulfinyl)-phenothiazine [as the besylate].

Brands
Adult Dose
Dose: 50 mg
Single Dose: 50 (50)
Frequency: As recommended.
Route: PO
Instructions: Starting dose
Neonatal
Paedriatic
Characteristics
belongs to Phenothiazine. . The Molecular Weight of Mesoridazine Besylate is 544.70.
Contraindications
Mesoridazine Besylate is contraindicated in conditions like CNS depression,Hypersensitivity to the drug.
Effects
Mesoridazine Besylate produces potentially life-threatening effects which include Arrhythmias. which are responsible for the discontinuation of Mesoridazine Besylate therapy.The signs and symptoms that are produced after the acute overdosage of Mesoridazine Besylate include Vomiting, Edema, Tachycardia, Coma, Dilated pupils, Ataxia, Tremor, Agitation, Congestive heart failure, Dystonia.The symptomatic adverse reactions produced by Mesoridazine Besylate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Vomiting, Constipation, Dry mouth, Hypotension.
Indications
Mesoridazine Besylate is primarily indicated in conditions like Schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice in Chronic alcoholism, Hyperactivity.
Interactions
Mesoridazine Besylate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementVORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
While ocular changes have not to date been related to Mesoridazine besylate, one should be aware that such changes have been seen with other drugs of this class. Because of ponoible hypotensive effects, reserve parenteral administration for bedfast patients or for acute ambulatory cases, and keep patient lying down for at least one-half hour after injection. Leokopenia and/or agranulocytosis have been attributed to phenothiazine therapy. A single case of transient granulocytopenia has been associated with mesoridazine besylate. Since convulsive seizures have been reported, patients receiving anticonvulsant medication should be maintained on that regimen while receiving mesoridazine besylate.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.