Mephentermine

A sympathomimetic agent with mainly indirect effects on adrenergic receptors. .It has alpha and beta adrenergic activity and a slight stimulating effect on CNS. It has an ionotropic effect on heart. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence.

Brands
Adult Dose
Dose: 30 to 45 mg
Single Dose: 38 (37.5)
Frequency: As recommended.
Route: IM
Instructions: 20 mins prior to anesthesia.
Neonatal
Paedriatic
Characteristics
Mephentermine Sulphate is the derivative of Mephentermine. It is of Synthetic origin and belongs to Sulphun. . The Molecular Weight of Mephentermine is 460.60.
Contraindications
Mephentermine is contraindicated in conditions like Cardiovascular disease,Pregnancy,Lactation.
Effects
The severe or irreversible adverse effects of Mephentermine, which give rise to further complications include Convulsions, Tachycardia, Hyperglycemia, Hyperglycemia, Tachycardia.The signs and symptoms that are produced after the acute overdosage of Mephentermine include Tachycardia, Convulsions, Drowsiness, Hallucinations, Palpitations, Anxiety.The symptomatic adverse reactions produced by Mephentermine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Anxiety, Dyspnea, Restlessness, Palpitation, Sweating, Confusion, Hallucination, Tremor, Hypertension, Incontinence, Confusion.
Indications
Mephentermine is primarily indicated in conditions like Hypotension, Hypotension during inhalational anesthesia.
Interactions
Mephentermine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementMethylamphetamineCentral nervous system (CNS) stimulants, particularly the amphetamines, can potentiate the adrenergic response to pressor agents. CNS stimulants often have peripheral sympathetic activity and can increase blood pressure and heart rate, thus they may have additive effects with pressor agents.ModerateCaution is advised if CNS stimulants are used with pressor agents. Pulse and blood pressure should be closely monitored. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Parentral Store Between 15°C-30°C. Do not Freeze.
Warnings
Precautions should be considered in: Pregnancy category C . Cardiovascular disease, chronically ill patients. Hemorrhagic shock, hyperthyroidism, hypertension.
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