COLCHICINE

Dose: 300 ug
Single Dose: 300 (300)
Frequency: 12 hourly
Route: PO
Instructions: Maintenance, As Required

Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:

Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:

. It is of Natural origin and belongs to Alkaloid. It belongs to Microtubule pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents and Colchicine pharmacological group.The Molecular Weight of Colchicine is 399.40. Its pKa is 1.7.

Colchicine is contraindicated in conditions like Blood dyscrasias,Renal diseases,Cardiac disease,GI diseases.

The severe or irreversible adverse effects of Colchicine, which give rise to further complications include Stomatitis, Paralytic ileus, Peripheral neuropathy, Azoospermia, Acute renal failure, Bladder spasm, Hypothyroidism, Non-thrombocytopenic purpuria, Vesicular dermatitis, Myopathy, Prostration.Colchicine produces potentially life-threatening effects which include Renal failure, Dehydration. which are responsible for the discontinuation of Colchicine therapy.The signs and symptoms that are produced after the acute overdosage of Colchicine include Nausea, Vomiting, Diarrhea, Stomatitis, Fever, Arthralgia, Cardiovascular collapse, Anorexia, Malaise, Rashes, Shock, Hypercalcemia.The symptomatic adverse reactions produced by Colchicine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Alopecia, Anorexia, Diarrhea, Abdominal pain, Rashes.

'Colchicine is primarily indicated in conditions like Acute gouty arthritis, Familial mediterranean fever, Gonadal dysgenesis (turner syndrome), Gout prophylaxis, Insomnia, Recurrent miscarriage (habitual abortion), Secondary amenorrhoea, Severe acute anxiety, Ventricular arrhythmias, and can also be given in adjunctive therapy as an alternative drug of choice in Parkinson''s disease or symptomatic parkinsonism.'

Colchicine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCyanocobalaminCyanocobalamincolchicine reduce GI absorptionCyclosporin AErythromycinHydroxocobalaminMecobalaminColchicine impairs cobalamin absorption.PitavastatinCases of myopathy, including rhabdomyolysis, have been reported when coadministered with colchicinecaution should be exercised when prescribing PITAVASTATIN with colchicineVORICONAZOLEVoriconazole may increase the serum concentration of colchicine by decreasing its metabolism. A dose reduction of colchicine is recommended along with increased monitoring for colchicine toxicity. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Increased Alkaline Phosphatase Levels

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Store at room temperature. Do not Freeze. Protect from Sunlight. Tab Store in a well closed container, Below 40°C. Protect from Sunlight.

It should be used with caution in debilitated patients or elderly patients or patients with severe GI, renal or liver disease. Perform periodic blood counts in patient receiving long-term therapy of colchicine.