Mechlorethamine

Mechlorethamine also known as mustine, nitrogen mustard, and HN2, is the prototype anticancer chemotherapeutic drug. Successful clinical use of mechlorethamine gave birth to the field of anticancer chemotherapy. The drug is an analogue of mustard gas and was derived from toxic gas warfare research. It belongs to the group of nitrogen mustard alkylating agents. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Brands
Adult Dose
Dose: 0.1 to 0.2 mg/kg
Single Dose: 0.15 (0.15)
Frequency: As recommended.
Route: IV
Instructions: per day
Neonatal
Paedriatic
Characteristics
belongs to Nitrogen Mustured alkylating agents. It belongs to Alkylating Agents pharmacological group on the basis of mechanism of action. The Molecular Weight of Mechlorethamine is 156.05. Its pKa is 6.1.
Contraindications
Mechlorethamine is contraindicated in conditions like Anaphylactic reactions.
Effects
The signs and symptoms that are produced after the acute overdosage of Mechlorethamine include Anemia, Jaundice, Leucopenia, Hypersensitivity reactions.The symptomatic adverse reactions produced by Mechlorethamine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Drowsiness, Alopecia, Anorexia, Diarrhea, Tinnitus, Depression, Nausea and vomiting, Alopecia.
Indications
'Mechlorethamine is primarily indicated in conditions like Hodgkin''s disease, and can also be given in adjunctive therapy as an alternative drug of choice in Bronchogenic carcinoma, Lymphosarcoma, Metastatic carcinoma, Polycythemia vera.'
Interactions
No data regarding the interactions of Mechlorethamine was found.
Interfrence
Liver Function Test (LFT)
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Parentrals Store Below 15°C. Protect from Sunlight and Moisture.
Warnings
Careful clinical judgment must be exercised in selecting patients. If the indication for its use is not clear, the drug should not be used. This drug is HIGHLY TOXIC and both powder and solution must be handled and administered with care. Appropriate protective equipment should be worn when handling MUSTARGEN. Should accidental eye contact occur, copious irrigation for at least 15 minutes with water, normal saline or a balanced salt ophthalmic irrigating solution should be instituted immediately, followed by prompt ophthalmologic consultation.Great care must be taken to avoid contact with eyes. Should accidental skin contact occur, the affected part must be irrigated immediately with copious amounts of water, for at least 15 minutes while removing contaminated clothing and shoes, followed by 2% sodium thiosulfate solution. Medical attention should be sought immediately. Contaminated clothing should be destroyed.
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