Mecamylamine

Mecamylamine is a potent, oral antihypertensive agent and ganglion blocker, and is a secondary amine. Mecamylamine is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. Mecamylamine reduces blood pressure in both normotensive and hypertensive individuals. A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced. Mecamylamine crosses the blood-brain and placental barriers.

Brands
Adult Dose
Dose: 25 mg
Single Dose: 25 (25)
Frequency: As recommended.
Route: PO
Instructions: 3 divided doses
Neonatal
Paedriatic
Characteristics
. The Molecular Weight of Mecamylamine is 167.29.
Contraindications
Mecamylamine is contraindicated in conditions like Glucoma,Myocardial infarction,Uremia,Pyloric stenosis,Hypersensitivity to the drug.
Effects
The signs and symptoms that are produced after the acute overdosage of Mecamylamine include Convulsions, Tremor, Paresthesia.The symptomatic adverse reactions produced by Mecamylamine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Fatigue, Anorexia, Constipation, Insomnia, Sedation, Nausea and vomiting, Dysarthria, Weakness.
Indications
Mecamylamine is primarily indicated in conditions like Hypertension.
Interactions
Mecamylamine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholThe action of Mecamylamine may be potentiated by alcohol.PropiomazineConcurrent use of mecamylamine with propiomazine may potentiate the hypotensive response, with increased risk of severe hypotension, shock, and cardiovascular collapse during surgery.Sodium CitrateSodium Citrate may decrease the excretion and increase the serum levels of Mecamylamine, possibly increasing their pharmacologic effects.sulfonamidePatients receiving antibiotics and sulfonamides generally should not be treated with ganglion blockers. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
'The patient''s condition should be evaluated carefully, particularly as to renal and cardiovascular function. When renal, cerebral, or coronary blood flow is deficient, any additional impairment, which might result from added hypotension, must be avoided. During therapy with Mecamylamine, sodium intake should not be restricted but, if necessary, the dosage of the ganglion blocker must be adjusted. Since urinary retention may occur in patients on ganglion blockers, caution is required in patients with prostatic hypertrophy, bladder neck obstruction, and urethral stricture. Frequent loose bowel movements with abdominal distention and decreased borborygmi may be the first signs of paralytic ileus. If these are present, Mecamylamine should be discontinued immediately and remedial steps taken.'
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