Iproniazid Phosphate

Iproniazid Phosphate a monoamine oxidase inhibitor (MAOI) that was developed as the first anti-depressant. It was originally intended to treat tuberculosis when it was discovered that patients given iproniazid became "inappropriately happy," subsequently with further research iproniazid was marketed specifically for depression in 1958. It was later replaced by less hepatotoxic drugs.

Brands
Adult Dose
Dose: 50 to 150 mg
Single Dose: 100 (100)
Frequency: As recommended.
Route: oral
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to hydrazine. . The Molecular Weight of Iproniazid Phosphate is 277.20.
Contraindications
Iproniazid Phosphate
Effects
The severe or irreversible adverse effects of Iproniazid Phosphate, which give rise to further complications include Hepatitis.The signs and symptoms that are produced after the acute overdosage of Iproniazid Phosphate include Convulsions, Porphyria, Delirium, Orthostatic hypotension, Euphoria.The symptomatic adverse reactions produced by Iproniazid Phosphate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Headache, Drowsiness, Fatigue, Constipation, Insomnia, Dry mouth, Nausea and vomiting, Dry mouth.
Indications
Iproniazid Phosphate is primarily indicated in conditions like Depression.
Interactions
Iproniazid Phosphate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcetohexamideTheoretical potential for IPRONIAZID increasing the HYPOGLYCAEMIC effect of ACETOHEXAMIDE. Potential risk. Reduce ACETOHEXAMIDE dose.AdrenalineLikely interaction of ADRENALINE increasing the VASOCONSTRICTOR effect of IPRONIAZID.ModerateAlprazolamInfrequent reports of ALPRAZOLAM increasing the EXTRAPYRAMIDAL side effects of IPRONIAZID.ModerateAmitriptyline (HCl)Infrequent reports of AMITRIPTYLINE increasing the SEROTONERGIC effect of IPRONIAZID. Potential risk. BromazepamInfrequent reports of BROMAZEPAM increasing the EXTRAPYRAMIDAL side effects of IPRONIAZID. ModerateBupropion (HCl)Likely interaction of IPRONIAZID increasing the CONVULSANT effect of BUPROPION. ModerateMay need to avoid combination.Buspirone (HCl)Theoretical potential for BUSPIRONE HYDROCHLORIDE increasing the HYPERTENSIVE effect of IPRONIAZID. Potential risk. AvoidCarbamazepineTheoretical potential for IPRONIAZID reducing the ANTICONVULSANT effect of CARBAMAZEPINE. Potential risk. AvoidChlordiazepoxide (HCl)Infrequent reports of CHLORDIAZEPOXIDE increasing the EXTRAPYRAMIDAL side effects of IPRONIAZID. Citalopram (HBr)Theoretical potential for IPRONIAZID increasing the SEROTONERGIC effect of CITALOPRAM..MajorClonazepamInfrequent reports of CLONAZEPAM increasing the EXTRAPYRAMIDAL side effects of IPRONIAZID. ModerateDiazepamInfrequent reports of DIAZEPAM increasing the EXTRAPYRAMIDAL side effects of IPRONIAZID. ModerateDisulfiramInfrequent reports of IPRONIAZID increasing the CNS TOXICITY of DISULFIRAM. MajorMay need to avoid combination.Dopamine (HCl)Likely interaction of DOPAMINE HYDROCHLORIDE increasing the HYPERTENSIVE effect of IPRONIAZID. MajorOxypertineTheoretical potential for OXYPERTINE increasing the CNS STIMULANT effect of IPRONIAZID. Moderate These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tablets Store in refrigerator.
Warnings
Not recommended for children. Care should be taken in glaucoma, prostatic enlargement. Avoid abrupt withdrawal. Withdraw IPRONIAZID gradually over several weeks.
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