Ipodate

Ipodate is a radiopaque contrast medium used in cholecystography and cholangiography.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. The Molecular Weight of Ipodate is 619.93.
Contraindications
Ipodate is contraindicated in conditions like Renal impairment.
Effects
The severe or irreversible adverse effects of Ipodate, which give rise to further complications include Allergic reactions, Hepatic impairment.The signs and symptoms that are produced after the acute overdosage of Ipodate include Bradycardia, Diarrhea.The symptomatic adverse reactions produced by Ipodate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Abdominal cramps, Nausea and vomiting, Heart burn.
Indications
Ipodate is primarily indicated in conditions like Hyperthyroidism of graves disease, and can also be given in adjunctive therapy as an alternative drug of choice in Cholecystography.
Interactions
Ipodate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcebutololLimited data suggest that patients receiving beta blockers may have an increased risk of severe hypotensive and/or hypersensitivity reactions to parenteral iodinated contrast media. In addition, the treatment of allergic/anaphylactoid reactions in these patients may be more difficult. The mechanism is unknown. ModeratePatients who have received beta blockers should be closely monitored for adverse reactions to iodinated contrast media. If anaphylaxis occurs, clinicians should be aware that beta blockers may attenuate the response to epinephrine. Thus, larger doses of epinephrine may be necessary to overcome the bronchospasm, although such large doses can also cause excessive alpha adrenergic stimulation resulting in hypertension, reflex bradycardia, heart block, and possible potentiation of bronchospasm. Alternative treatments recommended include vigorous supportive care (e.g., fluids) and the use of parenteral beta agonists for bronchospasm and norepinephrine for hypotension.AldesleukinAn increased incidence (12.6%) of acute, atypical reactions to iodinated contrast media has been observed in patients who have been previously treated with interleukin-2. The cause and mechanism have not been established. Symptoms generally have an onset of 1 to 4 hours and may include nausea, vomiting, diarrhea, fever, chills, flu-like symptoms, joint pain, rash, pruritus, hypotension, edema, and oliguria. Reactions have typically been reported when patients received iodinated contrast media within 4 weeks after the last dose of interleukin-2, but have also occurred several months after interleukin treatment.ModeratePatients should be monitored for adverse reactions after receiving iodinated contrast media, and symptomatic treatment initiated as clinically appropriate.CholestyramineCholestyramine may bind to oral iodine contrast agents and interfere with diagnostic testing. It is recommended that cholestyramine be discontinued prior to imaging with iodine contrast agents.MinorIoxilanRenal toxicity has been reported in a few patients with liver dysfunction who were given an oral cholecystographic agent followed by intravenous contrast agents. The mechanism of interaction has not been described. ModerateAdministration of any intravascular contrast agent should be deferred for 48 hours in patients with hepatic or biliary disorders who have recently received an oral cholecystographic contrast agent.MetrizamideRenal toxicity has been reported in a few patients with liver dysfunction who were given an oral cholecystographic agent followed by intravenous contrast agents. The mechanism of interaction has not been described.ModerateAdministration of any intravascular contrast agent should be deferred for 48 hours in patients with hepatic or biliary disorders who have recently received an oral cholecystographic contrast agent.Timolol (Maleate)Limited data suggest that patients receiving beta blockers may have an increased risk of severe hypotensive and/or hypersensitivity reactions to parenteral iodinated contrast media. In addition, the treatment of allergic/anaphylactoid reactions in these patients may be more difficult. The mechanism is unknown. ModeratePatients who have received beta blockers should be closely monitored for adverse reactions to iodinated contrast media. If anaphylaxis occurs, clinicians should be aware that beta blockers may attenuate the response to epinephrine. Thus, larger doses of epinephrine may be necessary to overcome the bronchospasm, although such large doses can also cause excessive alpha adrenergic stimulation resulting in hypertension, reflex bradycardia, heart block, and possible potentiation of bronchospasm. Alternative treatments recommended include vigorous supportive care (e.g., fluids) and the use of parenteral beta agonists for bronchospasm and norepinephrine for hypotension. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Thyroid Funtion Test
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tablets Store in a well closed container, Between 15°C-30°C.
Warnings
Make sure your doctor knows if you are planning to have any future thyroid tests. Patients sensitive to iodine or other iodinated contrast media may be sensitive to these agents also. The results of the thyroid test may be affected, even weeks or months later, by the iodine in this agent.
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