Clotrimazole

Clotrimazole is imidazole deriative that is a broad spectrum fungicidal drug. Clotrimazole is most valuable for the treatment of superficial fungal infection caused by dermatophytes, yeasts, and yeast like fungi. Clotrimazole is a topically used azole. The requirement for intravenous administration and the toxicity of the older antifungal agents created a need for antifungal agents with a better therapeutic profile. The relatively non-toxic oral azole medications represent the first major advance in this direction. Since their introduction in the 1980s, these medications have played an increasingly important role in the systemic therapy of fungal disease.


Brands
VANAZOLE GYNOSAFE GYNOSAFE CANESTEN VAGINAL CANESTEN VAGINAL CANESTEN VAGINAL CANESTEN TOPICAL BAYCUTEN-N BAYCUTEN-N TYCELEX TYCELEX TYCELEX CLOZOL CLOZOL CLOVAG IMEDIA CLOZE ZOLOTRIM FEMAZOL DERMOTRIM DERMOTRIM DERMOTRIM GYNY CLOTEEN V CANATRIM CLOTRIMAZOLE IMAZOLE IMAZOLE MYCOFAX LEUCONIL LEUCONIL FUNGESTIN YEAST YEAST GYNEMED GYNEMED FUNGISTA SPECTRAZOL-G SPECTRAZOLE SPECTRAZOLE SPECTRAZOLE GYNOSPORIN GYNOSPORIN GYNOSPORIN GYNOSPORIN DERMOSPORIN-B DERMOSPORIN DERMOSPORIN DERMOSPORIN DIPROCORT-C DIPROCORT-C CLOZOLE CLOZOLE CLOZOLE CLOMAZOL CLOMAZOL CLOMAZOL CLOMAZOL CLOMAZOL MYOPREX MYOPREX COSSET OLIGYN OLIGYN-1 OLIGYN-1 MIZOLE GYNAZOL GYNAZOL CLOTRIMA CLOTRIMA CLOZOX H CLOZOX CLOZOX CLOZOX CLOZOX HYDROZOLE STIEMAZOL STIEMAZOL CLOZIM-6 CLOZIM-1 GYNO-100 GYNO-500 GYNO CLOTRIM CLOTRIM CLOTRIM BETAZOLE BETAZOLE MACROLEX VAGINEX - I VEGIZOLE VEGIZOLE-V NOVESTEN TRICOSTEN TRICOSTEN CLINEX CLINEX VAGITRIM VAGITRIM BACIMYC CREAMAZOLE CREAMAZOLE CREMAZOLE-S CREAMAZOLE-H MEDIGYNE COGYNE CANAZOLE CANAZOLE DAVIZOL-V DAVIZOL-V CLORIZOLE EVAZOL VEGISET CALOTREN CALOTREN CALOTREN CLONIL VAG CTM CLONIL SKIN CLONIL SKIN GYNOZE-HC CLOTRI BIOTRIM AMCLOTRIM IPRA-SKIN ZEZOLE LOTRIGEN LOTRICORT LOTRICORT G LOTRICORT G GYTON GYTON VAGIZOLE VAGIZOLE VAGIZOLE ORIMAZOLE GYNOTEC GYNOTEC GYNOTEC ZAMITRO VAGINAL ZAMITRO VAGINAL ZAMITRO NORMOFLOR NORMOFLOR CLOKLEEN CLOKLEEN NOVIDAZOLE GYZAN GYZAN GYNOX-V DANSETEN IMIZOLE ARVIN ARVIN MYCELEX BECLOTRIM GYTRIM HC GYTRIM GYTRIM GYTRIM FUNGIGRAY-V FUNGIGRAY-V FUNGIGRAY-V GYNOTRIM MAK-MAZ CLOTRICON CLOTRICON MYCOVAG MYCOVAG M-GYNO COYZO CLOTEEN CLOTEEN CARA-CLOT CARA-CLOT DYMZOL CLOV FUNGIDERM FUNGIDERM MUPROCIN FRESNO FRESNO ALBIZOLE VAG TRIZEL CLOMISONE VAGIFEST TRIMAZOLE METHADO PRIZOLE SYDOTRIM VALE CLOTRIMAZOLE COLRIZOL DYMZOL VAG
Adult Dose
Dose: 1 % w/w
Single Dose: 1 (1)
Frequency: 24 hourly
Route: Intra Vaginal
Instructions: Apply at bedtime fpr 6-14 consecutive days.
Neonatal
Dose: 1%
Single Dose: 1 (1)
Frequency: 8 hourly
Route: Topical
Instructions:
Paedriatic
Dose: 1%
Single Dose: 1 (1)
Frequency: 8 hourly
Route: Topical
Instructions:
Characteristics
mycelax, mycelax are the derivatives of Clotrimazole. It is of Synthetic origin and belongs to Imidazole. It belongs to Dermatological Products and Antifungals pharmacological group.The Molecular Weight of Clotrimazole is 344.80.
Contraindications
Clotrimazole is contraindicated in conditions like Hypersensitivity.
Effects
The symptomatic adverse reactions produced by Clotrimazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Abdominal cramps, Pruritus, Sedation, Burning, Hallucination, Depression, Polyuria, Skin irritation, Disorientation, Contact dermatitis, Elevated serum llipids, Elevated alkaline phosphatase, Elevated hepatic transaminases, Vaginal irritation, GI irritation, Vision disturbances, Chemical cystitis, Hypersensitivity rash, urethral irritation.
Indications
Clotrimazole is primarily indicated in conditions like Advanced breast or prostate cancer, Erythrasma, Leishmaniasis, Mucocutaneous candidiasis, Oropharangeal candidiasis, Orophyrangeal candidiasis, Tinea corporis, Tinea cruris, Tinea pedis, Tinea versicolor, Trichomonal vaginitis, Vaginitis, Yeast infection, and can also be given in adjunctive therapy as an alternative drug of choice in Dermatophytic infections.
Interactions
Clotrimazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAliskiren These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Oint, Cream, Soln Store in a well closed container, at room temperature, Below 30°C or in refrigerator. Do not Freeze.
Warnings
Clotrimazole should be used cautiously during pregnancy. It should be used with caution in patients with medical history or allergies. Self-administration of clotrimazole for longer than 7 days is contraindicated. If there is no improvement in the condition after 3 days, or if the condition persists after 7 days, patient should discontinue the clotrimazole therapy and consult a physician. Topical application of clotrimazole is contraindicated in the children under the age of 2, unless recommended by the physician.
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