Glutethimide

Glutethimide is a hypnotic sedative,that was introduced in 1954 as a safe alternative to barbiturates to treat insomnia.


Brands
Adult Dose
Dose: 500 mg
Single Dose: 500 (500)
Frequency: 24 hourly
Route: PO
Instructions: Should be taken at bed time.
Neonatal
Paedriatic
Characteristics
. The Molecular Weight of Glutethimide is 217.26.
Contraindications
Glutethimide is contraindicated in conditions like Peptic ulcer,Porphyria.
Effects
The severe or irreversible adverse effects of Glutethimide, which give rise to further complications include Thrombocytopenia, Leucopenia, Agranulocytosis.The signs and symptoms that are produced after the acute overdosage of Glutethimide include Convulsions, Shortness of breadth, Fever, Weakness.The symptomatic adverse reactions produced by Glutethimide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Skin rash, Cramps, Nausea and vomiting, dizziness.
Indications
Glutethimide is primarily indicated in conditions like Insomnia, and can also be given in adjunctive therapy as an alternative drug of choice in Mydriasis induction.
Interactions
No data regarding the interactions of Glutethimide was found.
Interfrence
False +ve phentolamine test
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Protect from Sunlight, Moisture and Heat.
Warnings
Glutethimide will add to the effects of alcohol and other CNS depressants. (Causes Drowziness)
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