Nitroprusside

NITROPRUSSIDE is a vasodilator that relaxes blood vessels. It reduces blood pressure, increases the blood and oxygen supply to the heart, and decreases the workload on the heart. Nitroprusside helps to reduce blood pressure in a hypertensive (high blood pressure) emergency, and helps to lower the blood pressure during surgery to prevent excessive bleeding. Nitroprusside is not for long-term use. Generic nitroprusside injections are available.

Brands

Adult Dose

Dose: 10 to 800 mcg
Single Dose: 400 (405)
Frequency: As recommended.
Route: IV
Instructions:

Neonatal

Paedriatic

Characteristics

. The Molecular Weight of Nitroprusside is 297.95.

Contraindications

Nitroprusside is contraindicated in conditions like Renal failure.

Effects

Nitroprusside produces potentially life-threatening effects which include Tachycardia. which are responsible for the discontinuation of Nitroprusside therapy.The signs and symptoms that are produced after the acute overdosage of Nitroprusside include Cyanide toxicity.The symptomatic adverse reactions produced by Nitroprusside are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Sweating, Confusion, Pain, Redness, Hypotension, Flushing, Confusion, dizziness, Palpitations, Hypotension.

Indications

Nitroprusside is primarily indicated in conditions like Congestive heart failure, Hypertension, Hypertensive crisis, and can also be given in adjunctive therapy as an alternative drug of choice in Pre-eclampsia.

Interactions

Nitroprusside is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDeflazacortDiltiazem (HCl)Should not be use concurrently without doctor or pharmacist approval.Metoprolol (Tartrate)Should not be use concurrently without doctor or pharmacist approval.Propranolol (HCl)Should not be use concurrently without doctor or pharmacist approval.SildenafilShould not be use concurrently without doctor or pharmacist approval.Verapamil (HCl)Should not be use concurrently without doctor or pharmacist approval. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interfrence

Risks

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

Parenteral Store at room temperature. Protect from Sunlight.

Warnings

Blood pressure should be frequently monitored and recorded. Should be use with caution in patients with renal function. Because of its rapid onset, efficacy and short duration of action, nitroprusside should be administerd by infusiob pump and arterial blood pressure should be continuosly monitored via intra arterial recording. It Should be used with caution in hepatic impairment

Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.