Benzbromarone

Benzbromarone is a uricosuric drug that reduces plasma concentrations of uric acid by blocking renal tubular reabsorption. Benzbromarone may also increase the intestinal elimination of uric acid. It has been used to treat hyperuricaemia including that associated with chronic gout. Benzbromarone is not used to treat acute attacks of gout and may exacerbate and prolong them if given during an attack; treatment should not start therefore until an acute attack has subsided.


Brands
Adult Dose
Dose: 50 to 300 mg
Single Dose: 180 (175)
Frequency: As recommended.
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
.
Contraindications
Benzbromarone
Effects
The severe or irreversible adverse effects of Benzbromarone, which give rise to further complications include Hepatotoxicity, Renal calculi, Renal colic.The symptomatic adverse reactions produced by Benzbromarone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea.
Indications
Interactions
No data regarding the interactions of Benzbromarone was found.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Oint, Gel, Cream, Lotion, Oral Soln Store at room temperature, Below 30°C or in refrigerator. Do not Freeze. Protect from Sunlight.
Warnings
Benzbromarone should be avoided in patients with moderate or severe renal impairment, in those with uric acid renal calculi, and in those with urinary uric acid excretion rates of greater than 700 mg per 24 hours. Like other uricosurics, treatment with benzbromarone should not be started during an acute attack of gout. Similarly, an adequate fluid intake should be maintained to reduce the risk of uric acid renal calculi; additionally, alkalinisation of the urine may be considered.
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