Clopamide

Clopamide is a diuretic reduces the absorption of electrolytes from renal tubule. It increases the urination. Clopamide is used in hypertention to lower the high blood pressure and to treat edema associated with heart failure.


Brands
Adult Dose
Dose: 0.142 to 0.285 mg/kg
Single Dose: 0.21 (0.2135)
Frequency: 12 hourly
Route: PO
Instructions: As Required
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Piperidinyl Benzamide. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.The Molecular Weight of Clopamide is 345.80.
Contraindications
Clopamide is contraindicated in conditions like Gout,Maturity onset diabetes,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Clopamide, which give rise to further complications include Hypokalemia, Hyperglycemia, Precipitation of gout, Hyperglycemia.Clopamide produces potentially life-threatening effects which include Coronary insufficiency, Decreased BP. which are responsible for the discontinuation of Clopamide therapy.The symptomatic adverse reactions produced by Clopamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Gout, Renal failure, Hepatic failure.
Indications
Clopamide is primarily indicated in conditions like Congestive heart failure, Hepatic disease, Mild to moderate hypertension.
Interactions
Clopamide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbenoxolone (Na)LithiumNateglinideConcurrent use may reduce the hypoglycemic action of Nateglinide.Tetracycline (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Changes in plasma & white cell copper & zinc concentration.
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, at room temperature, Below 30°C.
Warnings
The drug should be used with extreme caution in diabetic patients because clopamide can worsen diabetic control, raising blood sugar level and may precipitate gout. It should be used with caution in combination with other antihypertensive drugs such as thiazide and loop diuretics, as it increases the urinary excretion of potassium and can cause hypokalemia, potassium supplements are used to treat hypokalemia.
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