Brotizolam

Brotizolam is a drug which is thienobenzodiazepine (a benzodiazepine derivative). It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties and is considered to be similar in effect to short-acting benzodiazepines such as triazolam. It is used in the short term treatment of insomnia although due to its short half life it is considered to have relatively high abuse potential and so would not be a first-line treatment.

Brands
Adult Dose
Dose: 0.5 to 1.5 mg
Single Dose: 1 (1)
Frequency: As recommended.
Route: oral
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Brotizolam is 393.70.
Contraindications
Brotizolam is contraindicated in conditions like Respiratory disease,Liver diseases,Close-angle glaucoma,Pregnancy,Lactation,Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Brotizolam, which give rise to further complications include Tachycardia, Urticaria, Jaundice, Dermatitis, Hypertension, Psychosis.The symptomatic adverse reactions produced by Brotizolam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Ataxia, Confusion, GI upset, Depression, Somnolence, Slurred speech, Hypersalivation.
Indications
Brotizolam is primarily indicated in conditions like Insomnia, and can also be given in adjunctive therapy as an alternative drug of choice in Premedication before surgery.
Interactions
No data regarding the interactions of Brotizolam was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tabs Store Below 30°C. Protect from Sunlight, Moisture and Heat.
Warnings
Brotizolam should not be stopped abruptly. Sudden discontinuation may lead to withdrawal symptoms. The dosage should be gradually reduced in accordance with the advice of your doctor. Short-term therapy is advised and treatment should generally be no longer than 4 weeks, including a tapering off process. Do not take brotizolam for longer periods unless expressly instructed by your doctor.
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