Cladribine

Cladribine is a drug used to treat hairy cell leukemia,it is commonly referred to as 2CDA.It interferes with the growth of cancer cells and slows their growth and spread in the body.


Brands
Adult Dose
Dose: 0.09 mg/kg/day
Single Dose: 0.09 (0.09)
Frequency: As recommended.
Route: IV
Instructions: Should be given for 7 consecutive days.
Neonatal
Paedriatic
Characteristics
2-CdA, 2-CdA are the derivatives of Cladribine. It is of Synthetic origin. . The Molecular Weight of Cladribine is 285.69.
Contraindications
Cladribine is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Cladribine, which give rise to further complications include Bleeding, Dizziness.The symptomatic adverse reactions produced by Cladribine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Constipation, Loss of appetite.
Indications
Cladribine is primarily indicated in conditions like Hairy cell leukaemia, Neutropenia, Thrombocythaemia, and can also be given in adjunctive therapy as an alternative drug of choice in Histiocytosis, Multiple sclerosis.
Interactions
No data regarding the interactions of Cladribine was found.
Interfrence
Liver Function Test (LFT)
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Protect from Sunlight.
Warnings
is a potent antineoplastic agent with potentially significant toxic side effects. It should be administered only under the supervision of a physician experienced with the use of cancer chemotherapeutic agents. Patients undergoing therapy should be closely observed for signs of hematologic and non-hematologic toxicity. Periodic assessment of peripheral blood counts, particularly during the first 4 to 8 weeks post-treatment, is recommended to detect the development of anemia, neutropenia and thrombocytopenia and for early detection of any potential sequelae (e.g., infection or bleeding).
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.