Dose: 300 to 500 mg
Single Dose: 400 (400)
Frequency: 8 hourly
Route: PO
Instructions: Each dose should be taken with meals.

. It is of Natural origin. .

'St.Johns Wort Extract is contraindicated in conditions like Schizophrenia,Pregnancy,Attention deficit hyperactivity disorder,Alzheimer''s disease,Breast feeding.'

The symptomatic adverse reactions produced by St.Johns Wort Extract are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Anxiety, Restlessness, Skin reactions, Dry mouth, Rashes, Pruritus, Sedation, Itching, Gastrointestinal disturbances.

St.Johns Wort Extract is primarily indicated in conditions like Anxiety disorder, Depression, Gastric ulcer, Kidney disease, Menopausal symptoms, Mood disorder, Premenstrual syndrome.

St.Johns Wort Extract is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAfatinibmay decreases the level of afatinib use alternative or increase daily dose of afatinibAmitriptyline (HCl)Significant reduction in amitriptyline concentrations were reported with concurrent ingestion of St. Johns wort.conjugated Estrogens/Bazedoxifenemay reduce plasma concentrations of estrogens, possibly resulting in a decrease in therapeutic effects monitor closelyCyclosporin AConcurrent use decrease the levels of Cyclosporin A.Dolutegravirdecreased level of dolutegravircoadministration should be avoidedErlotinibDecreased levels/effect of erlotinibEthinyloestradiolConcurent use may result in irregular menstrual flow.IloprostIrinotecan (HCl Trihydrate)MidazolamConcurrent use may decrease the midazolam concentrations.NevirapineThe oral clearance of nevirapine was significantly increased in patients treated with nevirapine and concomitant St. Johns wort.NifedipineConcurrent use may decrease the Nifedipine concentrations.PhenelzineConcurrent use can produce a dangerous rise in blood pressure or hypertensive crisis, along with severe anxiety, fever, muscle tension and confusion.SunitinibMay decrease sunitinib concentrations. St. Johns Wort may decrease its plasma concentrations unpredictably. Patients receiving sunitinib should not take St. Johns Wort concomitantly.TheophyllineSerum theophylline levels were decreased with concomitant ingestion of St. Johns wort.Tranylcypromine (Sulphate)Concurrent use can produce a dangerous rise in blood pressure or hypertensive crisis, along with severe anxiety, fever, muscle tension and confusion.VemurafenibSt.Johns Wort induces P-gp and CYP3A4.VORICONAZOLESt. Johns Wort may decrease the serum concentration of voriconazole by increasing its elimination.Concomitant therapy is contraindicatedVortioxetineincreases the toxicity of vortioxetineuse alternativeWarfarin (Na)Concurrent use may decrease the effects of Warfarin (Na). These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Elevated TSH levels

Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

'St. John''s Wort makes the skin more light sensitive. Persons with fair skin should avoid exposure to strong sunlight and other sources of ultraviolet light, such as tanning beds. These individuals may suffer a dermatitis, severe burning, and possibly blistering of the skin. The severity of these effects will depend on the amount of the plant consumed and the length of exposure to sunlight.St. John''s Wort should not be used at the same time as prescription antidepressants. Do not use St. John''s Wort during pregnancy or lactation.'