EPITRIL RIVOTRIL RIVOTRIL RIVOTRIL ZARON MAGURA MAGURA SETRIL SETRIL RETRIL CURO CURO EPIZEP EPIZEP EPIZEP CLONAZIL CLONAZIL CLONATRIL CLONATRIL NAZE NAZE NAZE EPPAM KLOZEPAM ROSPAM EPIFITS MEDYO MEDYO

Dose: 0.5 to 1 mg
Single Dose: 0.75 (0.75)
Frequency: 24 hourly
Route: PO
Instructions: Initial

Dose: 31.25 ug/kg
Single Dose: 31 (31.25)
Frequency: 24 hourly
Route: oral
Instructions: load for once

Dose: 25 ug/kg
Single Dose: 25 (25)
Frequency: 24 hourly
Route: Oral
Instructions: Initially at night

. It is of Synthetic origin and belongs to Benzodiazepines. It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Benzodiazepine pharmacological group.The Molecular Weight of Clonazepam is 315.70. Its pKa is 1.5, 10.5.

Clonazepam is contraindicated in conditions like Respiratory depression,Acute pulmonary insufficiency,Hypersensitivity.

The severe or irreversible adverse effects of Clonazepam, which give rise to further complications include Thrombocytopenia, Blood dyscrasias, Abnormal LFT.Clonazepam produces potentially life-threatening effects which include Apnea, Hypotension. which are responsible for the discontinuation of Clonazepam therapy.The signs and symptoms that are produced after the acute overdosage of Clonazepam include Drowsiness, Hypotonia, Ataxia, Somnolence.The symptomatic adverse reactions produced by Clonazepam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Fatigue, Anorexia, Tachycardia, Sleep disturbancesX, Rashes, VertigoX, Impotence, Loss of libido, SomnolenceX, Macular hypotonia, Coordination disturbances, Abnormal thirst, Skin pigmentation, Facial edema, Increased intracranial pressure, Vision disturbances.

Clonazepam is primarily indicated in conditions like All forms of epilepsy, Atypical absence, Bipolar affective disorder, Bipolar disorders, Choreiform movements, Drug induced dyskinesias, Epilepsy, Fulgurant pain, Infantile spasms, Lennox-gastaut syndrome, Myoclonic seizures, Myoclonus, Panic attack, Status epilepticus.

Clonazepam is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCarbamazepineCarbamazepine often reduces plasma concentration of Clonazepam.IprindoleTheoretical potential for CLONAZEPAM increasing the SEDATIVE effect of IPRINDOLE. ModerateIproniazid PhosphateInfrequent reports of CLONAZEPAM increasing the EXTRAPYRAMIDAL side effects of IPRONIAZID. ModerateLacosamidePhenobarbitonePhenytoin (Na)Phenytoin (Na)Valproic AcidConcurrent administration has been associated with the development of absence status epileptitis,however this complication appears to be rare.VORICONAZOLEVoriconazole may increase the serum concentration of clonazepam by decreasing its metabolism. Monitor for clonazepam toxicity if voriconazole is initiated or dose increased. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Liver Function Test (LFT) Periodic blood count

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Heat.

It should be used with caution in patients with chronic pulmonary insufficiency, or impairment of hepatic or renal function and in debilitated patients. Perform periodic blood counts and liver function tests during long term therapy. Clonazepam should be used with caution in patients if increased salivation cause respiratory difficulty, because it may produce an increase in salivation. Give least amount of drug to patients in whom depression accompanies anxiety and suicidal tendencies may be present. It should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity because it may cause allergic reaction (including bronchial asthma).