Pentostatin

Pentostatin is purine metabolite used as chemotherapeutic agent in cancer therapy particularly in hairy-cell leukemia.It is a potent inhibitor of adenosine deaminase and has immunosuppressive activity.it is isolated from fermentation cultures of streptomyces antibioticus.

Brands
Adult Dose
Dose: 4 mg/m2
Single Dose: 4 (4)
Frequency: As recommended.
Route: IV
Instructions: Antiemetic should be given for 48-74 hours after pentostatin administration.
Neonatal
Paedriatic
Characteristics
Pentostatin also known as deoxycoformycin, deoxycoformycin, deoxycoformycin, deoxycoformycin. . It is of Natural origin and belongs to purine analog. It belongs to Antimetabolites (DNA acting) pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent pharmacological group.The Molecular Weight of Pentostatin is 268.27.
Contraindications
Pentostatin is contraindicated in conditions like Pregnancy.
Effects
The severe or irreversible adverse effects of Pentostatin, which give rise to further complications include Anemia, Anemia, Hepatotoxicity, Neutropenia, Immune suppression, Anemia.Pentostatin produces potentially life-threatening effects which include Myelosuppression. which are responsible for the discontinuation of Pentostatin therapy.The signs and symptoms that are produced after the acute overdosage of Pentostatin include Renal insufficiency, Liver dysfunction, CNS effects.The symptomatic adverse reactions produced by Pentostatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fever, Abdominal pain, Chills, GI disturbance.
Indications
'Pentostatin is primarily indicated in conditions like Hairy cell leukaemia, and can also be given in adjunctive therapy as an alternative drug of choice in Non-hodgkin''s lymphoma, Non-hodgkin''s lymphoma.'
Interactions
No data regarding the interactions of Pentostatin was found.
Interfrence
SGPT level disturbance. Aspartate Aminotransferase Assay
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
If tiredness,anxiety,depression,sleep disturbance and paraesthesia occur medicine should be discontiued.Close monitoring of the patient should be done for bone marrow depression and other effects.
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