Dose: 50 to 100 mg
Single Dose: 75 (75)
Frequency: 24 hourly
Route: oral
Instructions: The dose is reduced to 25 mg in elderly and in patients with hepatic or renal impairment or patients taking CYP450 inhibitors

It belongs to Antihypertensive Agents pharmacological group.The Molecular Weight of Sildenafil is 666.70.

Sildenafil is contraindicated in conditions like Myocardial infarction,Peptic ulcer,Congestive heart failure,Hypotension,Unstable angina,Retinal damage,Stroke,Renal impairment,Hepatic impairment,Coagulation disorder,Arrhythmias.

The severe or irreversible adverse effects of Sildenafil, which give rise to further complications include Hypotension, Ventricular arrhythmia.Sildenafil produces potentially life-threatening effects which include Myocardial infarction, Sudden death, Stroke. which are responsible for the discontinuation of Sildenafil therapy.The signs and symptoms that are produced after the acute overdosage of Sildenafil include Diarrhea, Gastritis, Dyspepsia.The symptomatic adverse reactions produced by Sildenafil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Vomiting, Diarrhea, Dyspepsia, Flushing, Sneezing, Nasal congestion, Photophobia, Vison disturbance, Pulse irregularities.

Sildenafil is primarily indicated in conditions like Angina pectoris, Erectile dysfunction, Hypertension, and can also be given in adjunctive therapy as an alternative drug of choice in Oesophageal motility disorders, Priapism, Pulmonary hypertension, Raynaud`s phenomenon.

Sildenafil is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCimetidine (HCl)Clearance of Sildenafil is decreased due to inhibition of CYP450ErythromycinClearance of Sildenafil is decreased due to inhibition of CYP450ItraconazoleClearance of Sildenafil is decreased due to inhibition of CYP450KetoconazoleClearance of Sildenafil is decreased due to inhibition of CYP450NicorandilConcurrent use can cause a dangerous drop in blood pressure, therefore this combination should be avoided.NitrendipineBlood pressure-lowering effects may be additive.NitroglycerinSildenafil may exaggerate the blood pressure lowering effects of nitroglycerin and may cause excessive blood pressure reduction.Patients taking nitrates should not receive sildenafil.NitroprussideShould not be use concurrently without doctor or pharmacist approval.PrazosinWhen sildenafil is given with Alpha blockers (e.g.Prazosin) the hypotensive effect is enhancedRiociguatcause hypotensionMajorcontraindicatedVORICONAZOLEVoriconazole may increase the serum concentration of sildenafil by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Store Between 15°C-30°C. Do not Freeze.

If prolong erection and hypersensitivity to the drug develops consult your doctor.Do not use other impotence therapy agent with sildenafil.