CLOMIPRIL CLOMIPRIL CLOMIPRIL CLOMFRANIL CLOMFRANIL DENLA XR DENLA XR CLORIL CLOPRA TABLET CLOMIXET CLOMIXET ANAFRIL ANAFRIL UNIPRAMINE DEPRAMINE DEPRAMINE

Dose: 25 mg
Single Dose: 25 (25)
Frequency: 24 hourly
Route: PO
Instructions: Initial, gradually increased

Dose: 200 mg/day
Single Dose: 200 (200)
Frequency: 24 hourly
Route:
Instructions:

. It is of Synthetic origin and belongs to Imipramine. It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antidepressant pharmacological group.The Molecular Weight of Clomipramine (HCl) is 351.30. It is weakly alkaline drug and Its pKa is 9.5.

Clomipramine (HCl) is contraindicated in conditions like Cardiac arrhythmia,Mania,Myocardial infarction,Heart block,Narrow-angle glaucoma,Hypersensitivity,Urinary retention.

The severe or irreversible adverse effects of Clomipramine (HCl), which give rise to further complications include Parkinsonism, Jaundice, Seizures, Extrapyramidal symptoms, Bone marrow depression, Hypertension.Clomipramine (HCl) produces potentially life-threatening effects which include Cardiac Arrest, Mania, Stroke. which are responsible for the discontinuation of Clomipramine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Clomipramine (HCl) include Vomiting, Tachycardia, Convulsions, Coma, Drowsiness, Ataxia, Mydriasis, Agitation, Restlessness, Impaired impulse conduction, Stupor, Hyperactive reflexes, Muscular rigidity.The symptomatic adverse reactions produced by Clomipramine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Fatigue, Ataxia, Fever, Anxiety, Palpitation, Tremors, Abdominal pain, Blurred vision, Confusion, Pruritus, Erythema, Sedation, Photosensitivity, Hallucination, Weight gain, Disorientation, Reduced salivation, Micturition, Sexual dysfunction, Nightmares, Altered EEG, Numbness, Tingling, Peripheral neuropathy, Giddiness, Mydriasis, Xerostomia, Paresthesia of extremities, Delusion, Cycloplegia.

Clomipramine (HCl) is primarily indicated in conditions like Blocking-replacement, Cataplexy, Chronic diarrhoea in adults, Depression, Obsessive-compulsive disorders, Phobic states, and can also be given in adjunctive therapy as an alternative drug of choice in Autism, Pain, Premenstrual syndrome, Stuttering.

Clomipramine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholAmiodarone (HCl)Increased risk of ventricular arrhythmia when amiodarone given with tricyclic antidepressant (e.g clomipramine). ADVICE: Avoid concomitant use or only undertaken with caution and appropriate monitoring.MajorAntazolineIncreased antimuscarinic and sedative effects when antihistamines (e.g Antazoline) given with tricyclic antidepressants (e.g Clomipramine).Apraclonidine (HCl)Cimetidine (HCl)Clonidine (HCl)Fluoxetine (HCl)Fluvoxamine (Maleate)GestodeneGuanethidineHaloperidolIsocarboxazidMazindolMethylphenidate (HCl)MoclobemideNoradrenaline (Acid Tartrate)Phenytoin (Na)SulpirideVORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Caps Store in a well closed container, Below 40°C. Protect from Sunlight.

Clomipramine should be used with caution in patients with medical history, especially of glaucoma, prostate problems, decreased urine output, thyroid disease, breathing problems, seizure, alcohol use, heart disease, mental or emotional problems, liver or kidney disease and of any drug allergy. This medication can increase sensitivity to sunlight, avoid prolonged sun exposure, wear sunscreen and protective clothing. It should be used with caution in elderly persons because they are usually more sensitive to the effects of this medication. This drug should be used during pregnancy or lactation only if clearly needed.