Mazindol

Mazindol is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an anorectic or an anorexigenic drug.It stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite. Sympathomimetic appetite suppressants are used in the short-term treatment of obesity. Their appetite-reducing effect tends to decrease after a few weeks. Because of this, these medicines are useful only during the first few weeks of a weight-loss program mazindol is thought to inhibit the reuptake of norepinephrine rather than to cause its release.

Brands
Adult Dose
Dose: 1 to 2 mg
Single Dose: 1.5 (1.5)
Frequency: 8 hourly
Route: Oral
Instructions: Mazindol should be taken before meal.
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Isoindole. It belongs to CNS Stimulant and Adrenergic Agonist Agent pharmacological group.The Molecular Weight of Mazindol is 284.74.
Contraindications
Mazindol is contraindicated in conditions like Epilepsy,Hypertension,Hyperthyroidism,Cardiovascular disease,Arteriosclerosis.
Effects
The severe or irreversible adverse effects of Mazindol, which give rise to further complications include Allergic reactions, Restlessness, High blood pressure, Nervousness.Mazindol produces potentially life-threatening effects which include ciculatory collapse. which are responsible for the discontinuation of Mazindol therapy.The signs and symptoms that are produced after the acute overdosage of Mazindol include Seizures, Hyperthermia, Hallucinations, Tremor, Agressive behavior, Arrhythmias.The symptomatic adverse reactions produced by Mazindol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Irritability, Vomiting, Diarrhea, Insomnia, Swelling of face.
Indications
Mazindol is primarily indicated in conditions like Obesity, and can also be given in adjunctive therapy as an alternative drug of choice in Narcolepsy.
Interactions
No data regarding the interactions of Mazindol was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store in a well closed container, Below 30°C.
Warnings
Use caution while driving and operating machinery as it causes dizziness and tiredness. It is a habit forming drug so withdrawal effects occurs. It should be withdraw gradually.
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