Methazolamide

Methazolamide is an inhibitor of carbonic anhydrase.It is a sulfonamide derivative;however it does not have any clinically significant antimicrobial properties.


Brands
Adult Dose
Dose: 50 to 100 mg
Single Dose: 75 (75)
Frequency: 12 hourly
Route: oral
Instructions:
Neonatal
Paedriatic
Characteristics
It belongs to Carbonic Anhydrase Inhibitor pharmacological group on the basis of mechanism of action. The Molecular Weight of Methazolamide is 236.30. Its pKa is 7.30.
Contraindications
Methazolamide is contraindicated in conditions like Liver damage,Adrenal failure,Hyperchloremic acidosis.
Effects
The severe or irreversible adverse effects of Methazolamide, which give rise to further complications include Hypokalemia, Hyponatremia, Hyponatremia.The signs and symptoms that are produced after the acute overdosage of Methazolamide include Dizziness.The symptomatic adverse reactions produced by Methazolamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thirst, Fatigue, Nausea, Vomiting, Fever, Malaise, Tingling of the fingers and toes, Hearing disturbances.
Indications
Methazolamide is primarily indicated in conditions like Glucoma, Metabolic alkalosis, Urinary alkalinization, and can also be given in adjunctive therapy as an alternative drug of choice in Epilepsy.
Interactions
No data regarding the interactions of Methazolamide was found.
Interfrence
Serum electrophoresis Complete blood cell count
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store . Protect from Sunlight.
Warnings
Caution is to be taken when driving or operating dangerous machinery,and in patients on steroid therapy because of potential for developing hypokalemia.
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