Clomiphene (Citrate)

Clomiphene is a synthetic gonad stimulating principle structurally related to the proestrogen chlorotrianisene, consisting of a mixture of trans and cis isomers. Clomiphene (Citrate) is effective in treating infertility. It increases the secretion of gonadotropins and estrogens. It can also be used as a diagnostic agent. Administered orally.


Adult Dose
Dose: 50 mg
Single Dose: 50 (50)
Frequency: 24 hourly
Route: PO
Instructions: Initially For 5 Days
Neonatal
Dose: Not Inidicated in this Age Group
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: Not Inidicated in this Age Group
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
Clomiphene (Citrate) also known as Clomifene (Citrate). chloramiphene, chloramiphene, chloramiphene, chloramiphene are the derivatives of Clomiphene (Citrate). It is of Synthetic origin and belongs to Triaryl Ethylene. It belongs to Oestrogen antagonist pharmacological group on the basis of mechanism of action and also classified in Sex Hormones and Ovulation Stimulation pharmacological group.The Molecular Weight of Clomiphene (Citrate) is 598.10.
Contraindications
Clomiphene (Citrate) is contraindicated in conditions like Hyperprolactinaemia,Hepatic disease,Congenital disorders of bile disorders,Ovarian cysts,Abnormal uterine bleeding,Pituitary tumor.
Effects
The severe or irreversible adverse effects of Clomiphene (Citrate), which give rise to further complications include Ovarian enlargement, Rupture of lutein cysts, Intraperitoneal hemorrhage, palvic pain.Clomiphene (Citrate) produces potentially life-threatening effects which include ovarian cancer, Ovarian hyperstimulation. which are responsible for the discontinuation of Clomiphene (Citrate) therapy.The symptomatic adverse reactions produced by Clomiphene (Citrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Rashes, Depression, Weight gain, Loss of hair, Hot flushes, Blurring of vision, Breast tenderness, Abdominal discomfort, dizziness, sco to mota.
Indications
Clomiphene (Citrate) is primarily indicated in conditions like Anovulatory infertility, Polycystic ovary syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Secondary amenorrhoea.
Interactions
Clomiphene (Citrate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmobarbitalFollitropin BetaUrsodeoxycholic Acid These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increased in Serum Aminotransferase
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight.
Warnings
Clomiphene should not be used if patient have the following medical problems: liver disease, depression, ovarian cyst or blood clots. This drug is not recommended for use during pregnancy. Consult with doctor before lactation. Weight gain, electroyte imbalane
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