Troleandomycin

Troleandomycin is a prodrug of the macrolide antibacterial oleandomycin.Troleandomycin used majorly in the treatment of nose and throat infections and also in different bacterial infections.It functions similar to erythromycin but is less effective than that of erythromycin.

Brands
Adult Dose
Dose: 250 to 500 mg
Single Dose: 380 (375)
Frequency: 6 hourly
Route: oral
Instructions:
Neonatal
Paedriatic
Dose: 125 to 250 mg
Single Dose: 190 (187.5)
Frequency: 6 hourly
Route: oral
Instructions:
Characteristics
belongs to phenylethylamine. It belongs to microsomal enzyme inducer(CYP 450) pharmacological group on the basis of mechanism of action and also classified in Macrolide pharmacological group.The Molecular Weight of Troleandomycin is 149.23. It is weakly acidic drug.
Contraindications
Troleandomycin is contraindicated in conditions like Epilepsy,Heart disease,Arteriosclerosis.
Effects
The severe or irreversible adverse effects of Troleandomycin, which give rise to further complications include Liver dysfunction.Troleandomycin produces potentially life-threatening effects which include Ventricular arrhythmias. which are responsible for the discontinuation of Troleandomycin therapy.The signs and symptoms that are produced after the acute overdosage of Troleandomycin include Diarrhea, Nausea & vomiting, Abdominal discomfort.The symptomatic adverse reactions produced by Troleandomycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fever, Allergic reactions, stomach cramping.
Indications
Troleandomycin is primarily indicated in conditions like Appetite suppresser, and can also be given in adjunctive therapy as an alternative drug of choice in Obesity.
Interactions
Troleandomycin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementErlotinibThis CYP3A4 inhibitor increases levels/toxicity of erlotinib These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store in a well closed container, at room temperature.
Warnings
Tell your doctor if u have liver disease or if allergy occur. Avoid exposure to sunlight as it increases sensitivity of skin to sunlight. Consult doctor about using this medication in pregnant women.
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