Valproic Acid

Valproic acid is a chemical compound and clinically used as an anticonvulsant, epilepsy, bipolar disorders and mood-stabilizing drug by increasing brain concentration of GABA. Its anticonvulsant properties discovered by Pierre Eymard serendipitously when he use it as a vehicle for the number of compounds. Valproic acid is also an inhibitor of enzyme histone deacetylase 1. This enzyme is needed for HIV to remain in infected cells. thus use for the treatment of HIV and AIDS.

Brands
NEUROL-EP VALPORX
Adult Dose
Dose: 25 to 30 mg/kg/d
Single Dose: 28 (27.5)
Frequency: As recommended.
Route: oral,parenteral
Instructions:
Neonatal
Paedriatic
Characteristics
belongs to carboxalic acid. . The Molecular Weight of Valproic Acid is 144.21. Its pKa is 4.8.
Contraindications
Valproic Acid is contraindicated in conditions like Bone marrow depression,Coagulation disorder.
Effects
The severe or irreversible adverse effects of Valproic Acid, which give rise to further complications include Hepatotoxicity, Hepatitis, Tremors.The symptomatic adverse reactions produced by Valproic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Fatigue, Nausea, Dyspepsia, Weight gain, Hair loss.
Indications
Valproic Acid is primarily indicated in conditions like Bipolar disorders, Epilepsy, Seizures, and can also be given in adjunctive therapy as an alternative drug of choice in Migraine, Schizophrenia, Status epilepticus.
Interactions
Valproic Acid is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCholestyramineCoadministration of these drugs may lead to abnormal bleeding due to inability of blood to clot. Cholestyramine may reduce the absorption of valproic acid from intestine result in therapeutic inefficacy.ClonazepamConcurrent administration has been associated with the development of absence status epileptitis,however this complication appears to be rare.Lofepramine (HCl)Theoretical potential for VALPROIC ACID increasing the CONVULSANT effect of LOFEPRAMINE. ModerateMephenytoinValproic Acid may interact with Mephenytoin. It can either increase or decrease the effect of Mephenytoin. Phenobarbital SodiumValproic acid causes rise in plasma concentration of Phenobarbital sodium.Warfarin (Na)Coadministration of these drugs may lead to abnormal bleeding due to inability of blood to clot. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Between 15°C-30°C.
Warnings
Alcohol can potentiate to the drowsiness caused by this medication.Patients should be warned of weight gain and appropriate strategies adopted to minimise the effect.
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