Dose: 14.285 mg/kg
Single Dose: 14 (14.285)
Frequency: 12 hourly
Route: PO
Instructions: -

Dose: Not used in this age group
Single Dose:
Frequency:
Route:
Instructions:

Dose: 20 to 30 mg/kg
Single Dose: 25 (25)
Frequency: As recommended.
Route: Oral
Instructions: As Required

chlorfenicate, chlorfenicate, chlorfenicate are the derivatives of Clofibrate. It is of Synthetic origin and belongs to Propionic Acid. It belongs to Lipid lowering agents pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group.The Molecular Weight of Clofibrate is 242.70. Its pKa is 2.95.

Clofibrate is contraindicated in conditions like Gall stones,Impaired hepatic function,Hypoalbuminaemia,Impaired renal function,Gall bladder disease.

The severe or irreversible adverse effects of Clofibrate, which give rise to further complications include Diarrhoea, Impotence, Gall stones.Clofibrate produces potentially life-threatening effects which include Cardiac arrhythmias, Cholisthiasis, Thromboembolic disorders, Cholestasis. which are responsible for the discontinuation of Clofibrate therapy.The symptomatic adverse reactions produced by Clofibrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Nausea, Vomiting, Alopecia, Alopecia.

Clofibrate is primarily indicated in conditions like Hypercholesterolaemia, Hyperlipidaemia, Hyperlipidemia, Hyperlipoproteinaemia.

Clofibrate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCerivastatin SodiumCerivastatin sodium causes additive toxicity with clofibrateChlorpropamideDesmopressin (Acetate)Frusemide or FurosemideGliclazideLypressinPhenytoin (Na)Phenytoin (Na)RifampicinTocainide (HCl)TolbutamideTolbutamideVasopressinWarfarin (Na)Clofibrate may enhance the anticoagulant effect of Warfarin. MajorThe significance of this interaction may warrant a 25% to 33% reduction in the dosage of Warfarin if Clofibrate is to be started. Monitor for toxic effects of Warfarin if Clofibrate is initiated/dose increased, or decreased effects if Clofibrate is discontinued/dose decreased. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Lower Urinary VMA Excretion. Raise estimates of serum protein bound iodide & aspartate transaminase. Increased creatinene phosphokinesdecresed alkaline phosphate

Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Caps Store in a well closed container, Below 40°C. Protect from Sunlight and Heat.

Withdraw the drug after 3 months if adequate response is not achieved. It should be used with caution in patients with history of liver disease, jaundice or peptic ulcer. Perform complete blood count periodically because anemia and leukopenia have been reported in patients taking clofibrate.