Quinupristin

Quinupristin is semisynthetic derivative of naturally occuring pristinamycins, produced by Streptomyces pristinaespiralis.It is a protein synthesis inhibitor that binds the 50 S ribosomal subunit with inhibition of polypeptide elongation and early termination of protein synthesis.Quinupristin is approved for treatment of infections caused by Vancomycin-resistant strains of E. faecium and complicated skin and skin structure infections caused by Methicillin resistant strains of S. aureuses or S. pyogens. Quinupristin should be reserved for the treatment of serious infections caused by multiple drug resistant gram-positive organisms such as vancomycin- resistant E.faecium.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
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Contraindications
Quinupristin is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The symptomatic adverse reactions produced by Quinupristin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Myalgia, Pain, Phlebitis, Arthralgia.
Indications
Quinupristin is primarily indicated in conditions like Extravasation/haematoma, Skin infections.
Interactions
No data regarding the interactions of Quinupristin was found.
Interfrence
Increased level of Blood urea nitrogen (BUN) concentrationsMonitoring of ALT AND AST levelIncreased concentration of creatinine kinase
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Cocomitant use of quinupristin with the drugs that are metabolized by CYP3A4 may enhance drug effects and result in siginificant toxicity. Appropriate caution monitoring are recommended for drugs in which the toxic therapeutic windows is narrow or for the drugs that cause QTc prolongation (e.g. antihistamines).
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