Duloxetine Hydrochloride

Duloxetine hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration. Its chemical designation is (+)-(S)-N-methyl-?-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride. The empirical formula is C18H19NOS€¢HCl. Duloxetine hydrochloride is a white to slightly brownish white solid, which is slightly soluble in water.


Adult Dose
Dose: 40 to 60 mg/day
Single Dose: 50 (50)
Frequency: As recommended.
Route: PO
Instructions: For major depression:
Neonatal
Paedriatic
Characteristics
Duloxetine is the derivative of Duloxetine Hydrochloride. It is of Synthetic origin. . The Molecular Weight of Duloxetine Hydrochloride is 333.90. It is weakly alkaline drug.
Contraindications
Duloxetine Hydrochloride
Effects
The severe or irreversible adverse effects of Duloxetine Hydrochloride, which give rise to further complications include Hyponatremia, Hyponatremia.The symptomatic adverse reactions produced by Duloxetine Hydrochloride are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Thirst, Fatigue, Nausea, Vomiting, Diarrhea, Constipation, Insomnia, Sweating, Blurred vision, Pruritus, Lethargy, Dyspepsia, Weight gain, Somnolence, Tremor, Sexual dysfunction, Syncope, Decrease in libido, dyspepsia.
Indications
Duloxetine Hydrochloride is primarily indicated in conditions like Anxiety disorder, Depression, Urinary incontinence, and can also be given in adjunctive therapy as an alternative drug of choice in Moderate to severe stress urinary incontinence in women.
Interactions
Duloxetine Hydrochloride is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholOxymorphoneCentral nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.ModerateDuring concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increased Alkaline Phosphatase Elevation in ALT or AST
Risks
Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Elderly, History of mania, History of seizures; Raised ocular pressure, Acute narrow- angle glucoma; Concomitant use of drugs that increase risk of bleeding; Suicidal thoughts or behaviour; assess benefit of treatment periodically; avoid abrupt withdrawl. The drug should not be administered to lactating mothers, pregnant mothers and hepatic patients.
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