Tamsulosin Hydrochloride

It is used in the symptomatic treatment of urinary obstruction caused by benign prostatic hyperplasia. It is alpha 1 adrenocetor blocker, more selective for alpha 1A adrenoceptor sub type.


Adult Dose
Dose: 0.4 mg
Single Dose: 0.4 (0.4)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
.
Contraindications
Tamsulosin Hydrochloride is contraindicated in conditions like Acute and chronic psychoses,Postural hypotension,Hepatic impairment.
Effects
The symptomatic adverse reactions produced by Tamsulosin Hydrochloride are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Palpitation, Tachycardia, Dry mouth, Blurred vision, Hypotension, Depression, Asthenia, Hypersensitivity, Edema, Syncope, Rhinitis, Erectile disturbance, Gastrointestinal disturbances.
Indications
Tamsulosin Hydrochloride is primarily indicated in conditions like Benign prostatic hyperplasia, Primary nocturnal enuresis.
Interactions
Tamsulosin Hydrochloride is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCimetidine (HCl)Concurrent use causes significant changes in both tamsulosin hydrochloride clearance (26% decrease) and exposure (44% increase in AUC). Clonidine (HCl)Concomitant use of these two drugs can potentially cause symptomatic hypotension. ErythromycinTamsulosin Hydrochloride should be used with caution in combination with Erythromycin.KetoconazoleTamsulosin is extensively metabolized, mainly by CYP3A4 and CYP2D6. Therefore should not be used in combination with strong inhibitors of CYP3A4 e.g Ketoconazole.ParoxetineTamsulosin Hydrochloride should be used with caution in combination with Paroxetine.Terbinafine (HCl)Tamsulosin Hydrochloride should be used with caution in combination with Terbinafine (HCl).VORICONAZOLEVoriconazole may increase the serum concentration of tamsulosin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects Warfarin (Na)Concomitant use of these two drugs can potentially cause symptomatic hypotension. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store in a well closed container, Between 15°C-30°C. Protect from Sunlight, Moisture and Heat.
Warnings
Selective alpha blockers reduce blood pressure. Patient receiving antihypertensive treatment may require reduced dosage and specialist supervision
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.