Trilostane

Trilostane is useful in cushing''s syndrome & primary hyperaldosteronism. It reversibly inhibits β hydroxysteroid dehydrogenase/delta 5-4 isomerase in the adrenal cortex; the resulting inhibition of the synthesis of mineralocorticoids and glucocorticoids may be useful in cushing''s syndrome. It has minor role in post menopausal breast cancer that has relapsed following initial estrogen antagonist therapy.'

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Trilostane is 329.40.
Contraindications
Trilostane is contraindicated in conditions like Pregnancy,Breast feeding.
Effects
The symptomatic adverse reactions produced by Trilostane are more or less tolerable and if they become severe, they can be treated symptomatically, these include Rashes, Flushing, Tingling, Mouth swelling, Granulocytopenia (rarely).
Indications
'Trilostane is primarily indicated in conditions like Cushing''s syndrome, Post menopausal breast cancer (with glucocorticoid therapy), Primary hyperaldosteronism, and can also be given in adjunctive therapy as an alternative drug of choice in Adrenal cortical hyperfunction, Prophylaxis of macrocytic anaemias.'
Interactions
No data regarding the interactions of Trilostane was found.
Interfrence
Risks
Drug should not be given to Paediatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Breast cancer (concurrent mineralocorticoid & glucocorticoid therapy may be needed). Adrenal cortical hyperfunction (tailored to cortisol and electrolytes, concurrent corticosteroid therapy may be needed): hepatic & renal impairrment.
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