Clofazimine

Clofazimine is a phenazine dye. Clofazimine is used in the treatment of leprosy. Clofazimine is usually used in combination with other anti-leprosy medication such as dapsone.A fat soluble riminophenazine dye used for treatment --- . it has been used investigationally in combination with other antimyobacterial drugs to treat mycokacterium avium infect in AIDS patients.Its has moved anti-inflamatory effect is given to control the leprosy reaction,erythma leprosum.

Brands
Adult Dose
Dose: 1.428 mg/kg
Single Dose: 1.4 (1.428)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Dose: 6.25 mg/kg
Single Dose: 6.2 (6.25)
Frequency: 12 hourly
Route: oral
Instructions: Initial, weekly
Paedriatic
Dose: 4.166 mg/kg
Single Dose: 4.2 (4.166)
Frequency: As recommended.
Route: Oral
Instructions: Initially on alternate days
Characteristics
Chlofazimine, Chlofazimine, Chlofazimine are the derivatives of Clofazimine. It is of Synthetic origin and belongs to Riminophenazine. It belongs to Antimycobacterial agent pharmacological group on the basis of mechanism of action and also classified in Leprostatics pharmacological group.The Molecular Weight of Clofazimine is 473.40.
Contraindications
Clofazimine is contraindicated in conditions like Diarrhoea,Peptic ulcer,Vomiting,Steatorrhoea.
Effects
The severe or irreversible adverse effects of Clofazimine, which give rise to further complications include Diarrhoea, Gi bleeding, GI bleeding, Bowel irregularity, Bowel obstruction, Bowel obstruction.Clofazimine produces potentially life-threatening effects which include Mucosal pattern coarsen, Nodular or polypoid changes, Eosinophilic enteritis, Drug crystals deposition. which are responsible for the discontinuation of Clofazimine therapy.The symptomatic adverse reactions produced by Clofazimine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Anorexia, Abdominal pain, Pruritus, Skin discoloration, Hair discoloration, Dry skin, Dermatitis, Acneform, Eruptions, Phototoxicity.
Indications
Clofazimine is primarily indicated in conditions like Discoid lupus erythematosus, Erythema nodosum leprosy, Leprosy, Multibacillary leprosy, Pustular psoriasis, Pyoderma gangrenosum, Renal transplant, Vitiligo.
Interactions
Clofazimine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDapsoneRifampicinRifampicin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increases Serum Bilirubin Elevation in ALT or AST
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store in a well closed container, at room temperature, Between 15°C-30°C. Protect from Sunlight, Moisture and Heat.
Warnings
Clofazimine should be used with caution in patients with any pre-existing stomach disorders or any allergy. It should be used with caution when driving or operating machinery because it may cause dizziness. This medication should be used only if clearly needed during pregnancy or lactation.
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