Pemetrexed

Pemetrexed is an anti-cancer chemotherapy drug. It is classified as an antimetabolite. It is used in the treatment of malignant mesothelioma.

Brands
ALIMTA TREXAM
Adult Dose
Dose: 500 mg/m2
Single Dose: 500 (500)
Frequency: As recommended.
Route: IV
Instructions: Pemetrexed is given in the form of Pemetrexed disodium infused over 10 min on day 1 of each 21-day cycle.
Neonatal
Paedriatic
Characteristics
.
Contraindications
Pemetrexed is contraindicated in conditions like Thrombocytopenia,Renal diseases,Pregnancy,Lactation.
Effects
The symptomatic adverse reactions produced by Pemetrexed are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fatigue, Anorexia, Fever, Constipation, Mouth ulcers, Depression, Nausea and vomiting, Numbness, Tingling of the hand, Chest pain, Anemia, Leucopenia, Low platelet count, Increase in blood test creatinine.
Indications
Pemetrexed is primarily indicated in conditions like Mesothelioma, Non-small cell lung carcinoma.
Interactions
No data regarding the interactions of Pemetrexed was found.
Interfrence
Elevation in ALT or AST
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
'Before starting premetrexed treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this. Do not take non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprophen unless your doctor specifically permits this. Do not receive any kind of immunization or vaccination without your doctor''s approval while taking premetrexed. Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (premetrexed may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus.) For both men and women: Do not conceive a child (get pregnant) while taking premetrexed. Do not breast feed while taking this medication.'
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