Dose: 56.25 to 75 mg/day
Single Dose: 66 (65.625)
Frequency: As recommended.
Route: PO
Instructions: The recommended starting dose is 37.5 mg/day. The maximum recommended daily dose of pemoline is 112.5 mg.

Dose: 75 to 56.25 mg
Single Dose: 66 (65.625)
Frequency: 24 hourly
Route: PO
Instructions: The max. recommended daily dose is 112.5 mg.

. The Molecular Weight of Pemoline is 176.20.

Pemoline is contraindicated in conditions like Liver diseases.

The severe or irreversible adverse effects of Pemoline, which give rise to further complications include Growth inhibition, Mania.The signs and symptoms that are produced after the acute overdosage of Pemoline include Choreoathetosis, Rhabdomyolysis, Chorea.The symptomatic adverse reactions produced by Pemoline are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fever, Abdominal pain, Neutropenia, Tics.

Pemoline is primarily indicated in conditions like Labyrinthine disorders, Prostate cancer, long-term palliative therapy.

Pemoline is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDiazepamPemoline may decrease seizure threshold. Efficacy of anticonvulsants may be decreased LorazepamPemoline may decrease seizure threshold. Efficacy of anticonvulsants may be decreased MidazolamPemoline may decrease seizure threshold. Efficacy of anticonvulsants may be decreased MolindoneConcurrent use with Molindone increases certain serious side effects.Phenobarbital SodiumEffects may be additive. Use caution when pemoline is used with other CNS acting medicationsPhenobarbitoneEffects may be additive. Use caution when pemoline is used with other CNS acting medications These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Liver Function Test (LFT)

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Pemoline should be used only after other treatments have failed. If this drug fails to work within a reasonable amount of time (within 3 weeks after ideal dosage has been determined) its use should be stopped. This medication has rarely caused severe (sometimes fatal) liver problems.Pemoline should be used only after other treatments have failed. If this drug fails to work within a reasonable amount of time (within 3 weeks after ideal dosage has been determined) its use should be stopped. This medication has rarely caused severe (sometimes fatal) liver problems.