Aripiprazole

Atypical antipsychotic, having less axtrapyramidal symptoms than older antipsychotics. It is used to treat schizophrenia. Atypical antipsychotics should be used with caution in patients with cardiovascular disease, or a history of epilepsy.


Adult Dose
Dose: 15 to 30 mg
Single Dose: 22 (22.5)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Aripiprazole is 448.39.
Contraindications
Aripiprazole is contraindicated in conditions like Breast feeding.
Effects
The symptomatic adverse reactions produced by Aripiprazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Tachycardia, Constipation, Insomnia, Blurred vision, Akathisia, Dyspepsia, Somnolence, Tremor, Postural hypotension, Asthenia, Light headedness, Seizures.
Indications
Aripiprazole is primarily indicated in conditions like Schizophrenia.
Interactions
Aripiprazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementLacosamideVORICONAZOLEay increase the serum concentration of aprepitant by decreasing its metabolism.discountied or dose changed These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Cardiac / Hypertensive Patients, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tablets,solutions Store at room temperature, . Protect from Sunlight, Moisture and Heat.
Warnings
While atypical antipsychotics have not generally been associated with clinical significant prolongation of the QT interval, they should be used with care if prescribed with other drugs that increase the QT interval. It should be used with caution in patients with cardiovascular disease, or a history of epilepsy; they should be used with caution in the elderly. It may affect performance of skilled tasks (e.g. driving). Withdrawal of antipsychotic drugs after long-term therapy should always be gradual and closely monitored to avoid the risk of acute withdrawal syndromes or rapid relapse.
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