Clobetasone (Butyrate)

Clobetasone (Butyrate) is a topical corticosteroid and used to treat swelling, inflammation, or itching of skin conditions such as eczema, dermatitis, rashes, insect bites, allergies and other irritations.


Adult Dose
Dose: 0.05 to 0.1 mg
Single Dose: 0.075 (0.075)
Frequency: 6 hourly
Route: Ophthalmic
Instructions: -
Neonatal
Dose: Should not be used in this age group
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: 0.05 to 0.1 mg
Single Dose: 0.075 (0.075)
Frequency: 6 hourly
Route: Opthalmic
Instructions: -
Characteristics
. It is of Synthetic origin and belongs to Corticosteroid. It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Adrenal Cortical Steroids and Anti-inflammatory pharmacological group.The Molecular Weight of Clobetasone (Butyrate) is 479.00. Its pKa is not ionized.
Contraindications
Clobetasone (Butyrate) is contraindicated in conditions like Acne vulgaris,Rosacea,Perioral dermatitis,Hypersensitivity,Infestations.
Effects
The severe or irreversible adverse effects of Clobetasone (Butyrate), which give rise to further complications include Telangiectasia, Striae, Glaucoma, Minor atrophic changes, Epidermis atrophy, Dermal collagen atrophy, Perioral dermatitis, Skin ulceration.The symptomatic adverse reactions produced by Clobetasone (Butyrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Allergy, Glaucoma, Cataract.
Indications
Clobetasone (Butyrate) is primarily indicated in conditions like Dermatitis, Eczema, Herpes simplex infections, Inflammatory eye disease, Psoriasis.
Interactions
No data regarding the interactions of Clobetasone (Butyrate) was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Cream, Oint, Eye Drops Store in a well closed container, Below 25°C. Protect from Sunlight.
Warnings
Clobetasone should be used with caution in patients with active tuberculosis infection of respiratory tract or in untreated fungal, bacterial or systemic viral infections. Corticosteroids should only be used systemically with great caution in the presence of congestive heart failure (CHF), recent myocardial infraction (MI), hypertension, diabetes mellitus, epilepsy, glaucoma, hypothyroidism, liver failure, osteoporosis, peptic ulceration or renal impairment. Children may be at increase risk of some adverse effects, corticosteroid causes growth retardation and prolonged use is rarely justified. Passive immunization is recommended to non-immune patients who do come in contact with chickenpox or measles. Live vaccine should not be given to patients receiving high dose systemic corticosteroid therapy nor for atleast 3 months afterwards, killed vaccine or toxoids may be given, although the response may be attenuated. During prolong treatment with corticosteroids, patients should be examined regularly, sodium intake may need to be reduced and calcium and potassium supplement may be necessary. Patient should carry cards given full details of their corticosteroid therapy. Avoid use during pregnancy. Use nasal steroids with caution until healing has occurred.
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