OXITAN OXITAN DABENZOLE DABENZOLE XALIPLATIN XALIPLATIN OXALTIE OXALTIE OXALITIN OXALITIN PLAXINOL OXALIPLATIN OXALIPLATIN ELOXATIN ELOXATIN OXALIPLATIN AHP FOR OXALIPLATIN AHP FOR KEBIR KEBIR

Dose: 85 mg/sq. metre
Single Dose: 160 (156)
Frequency: As recommended.
Route: IV
Instructions: Every 2 weeks

. It is of Synthetic origin. . The Molecular Weight of Oxaliplatin is 397.30.

Oxaliplatin is contraindicated in conditions like Peripheral neuropathy,Pregnancy,Breast feeding.

The severe or irreversible adverse effects of Oxaliplatin, which give rise to further complications include Bone marrow depression.The symptomatic adverse reactions produced by Oxaliplatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Alopecia, Ototoxicity, Myelosuppression, Nausea and vomiting, Gastrointestinal disturbances, Sensory peripheral neuropathy.

Oxaliplatin is primarily indicated in conditions like Cervical carcinoma, Cyclical benign breast disease, Germ cell tumors, Neurogenic bladder, Ovarian cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Severe nausea, vomiting (acute attacks).

Oxaliplatin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmikacin (Sulphate)You should inform your doctor before using this combination.Do not start or stop any medicine without doctor or pharmacist approval.Amphotericin BYou should inform your doctor before using this combination.Do not start or stop any medicine without doctor or pharmacist approval.Cyclosporin AYou should inform your doctor before using this combination.Do not start or stop any medicine without doctor or pharmacist approval.GentamicinYou should inform your doctor before using this combination.Do not start or stop any medicine without doctor or pharmacist approval.IbuprofenYou should inform your doctor before using this combination.Do not start or stop any medicine without doctor or pharmacist approval.TacrolimusYou should inform your doctor before using this combination.Do not start or stop any medicine without doctor or pharmacist approval.Vancomycin (HCl)You should inform your doctor before using this combination.Do not start or stop any medicine without doctor or pharmacist approval. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Liver Function Test (LFT) Monitoring of hematologic profileMonitoring of ALT AND AST level

Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Oxaliplatin in combination with fluorouracil and folinic acid, should be considered first-line treatment for advanced colorectal cancer only in patients with metastases which are confined to liver and which could be resected following treatment. Oxaliplatin causes mild renal impairment, so manufacturers advise avoid if creatinine clearance less than 30 ml/min.