Procaine

Procaine is a local anesthetic drug of amino ester group.It was first synthesized in 1905.

Brands
CARDIOPLEGIA
Adult Dose
Neonatal
Paedriatic
Characteristics
Procaine (HCl) is the derivative of Procaine. It is of Synthetic origin and belongs to P-aminobenzoic acid ester. . The Molecular Weight of Procaine is 236.31. Its pKa is 8.05.
Contraindications
Procaine is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Procaine, which give rise to further complications include Convulsions, Allergic reactions, Anxiety, Dizziness, Chest pain.The symptomatic adverse reactions produced by Procaine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Pain, Numbness, Tingling.
Indications
Procaine is primarily indicated in conditions like Dental surgery, Local anaesthesia, Surgical anaesthesia.
Interactions
Procaine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcepromazine (Maleate)AmethocaineSulfanilamideDecreased effect of sulfonamides with the PABA metabolite of procaine.SulphadiazineDecreased effect of sulfonamides with the PABA metabolite of procaine.SulphamethizoleSulfonamides may be antagonized by para-aminobenzoic acid and its derivaties like procaine group of anesthetics.SulphamethoxazoleDecreased effect of sulfonamides with the PABA metabolite of procaine. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Avoid injury to the area where procaine is injected. Before using procaine, talk to your healthcare provider if you have liver problems, bleeding or blood clotting problems, heart problems,a neuromuscular disease such as myasthenia gravis or other serious medical conditions.
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