FRISIUM CLOBAM LOBAZIUM

Dose: 20 to 30 mg
Single Dose: 25 (25)
Frequency: As recommended.
Route: PO
Instructions: Usually in divided doses. Max dose 60 mg.

Dose: 0.2 to 1 mg/kg
Single Dose: 0.6 (0.6)
Frequency: 12 hourly
Route: oral
Instructions:

Dose: 0.33 to 0.5 mg/kg
Single Dose: 0.41 (0.415)
Frequency: 8 hourly
Route: Oral
Instructions:

. It is of Synthetic origin and belongs to Benzodiazepines. It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Sedatives and Hypnotics and Benzodiazepine pharmacological group.The Molecular Weight of Clobazam is 300.70. Its pKa is

Clobazam

The severe or irreversible adverse effects of Clobazam, which give rise to further complications include Drug dependence.Clobazam produces potentially life-threatening effects which include Blood dyscrasias. which are responsible for the discontinuation of Clobazam therapy.The signs and symptoms that are produced after the acute overdosage of Clobazam include Emesis, Muscular weakness.The symptomatic adverse reactions produced by Clobazam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Drowsiness, Ataxia, Nausea, Dry mouth, Light headedness, Paradoxical effects, Amnesia, Dry mouth, dizziness, Ataxia.

Clobazam is primarily indicated in conditions like Adjunct in epilepsy, Anxiety states in psychotic disorders, Epilepsy, Primary anxiety, Sleep disturbances, Suppression of transplant rejection.

Clobazam is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCarbamazepineCimetidine (HCl)OmeprazolePhenytoin (Na)PropoxypheneVORICONAZOLEVoriconazole may increase the serum concentration of clobazam by decreasing its metabolism. .Monitor for clobazam toxicity if voriconazole is initiated or dose increased These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store in a well closed container, Below 25°C.

Clobazam should be used with caution in patients with acute respiratory depression, respiratory insufficiency, pregnancy and lactation, withdraw gradually.