Gallamine Triethiodide

Gallamine Triethiodide is a benzylisoquinolinium, a competative neuromuscular blocker similar to atracurium. Gallamine Triethiodide is used to produce muscle relaxation in general anaesthesia for surgical procedures and also to assist mechanical ventilation. It has parasympatholytic and sympathomimetic properties and frequently increases pulse rate and blood pressure.

Brands
Adult Dose
Dose: 1 mg/kg
Single Dose: 1 (1)
Frequency: As recommended.
Route: IV
Instructions: For surgery: If necessary, repeated doses of 0.5 to 1 mg/kg or less, at intervals of 50 to 60 minutes or longer, may be given.
Neonatal
Paedriatic
Characteristics
belongs to Benzyl isoquinolinium. . The Molecular Weight of Gallamine Triethiodide is 891.50. It is weakly acidic drug and Its pKa is 13-14.
Contraindications
Gallamine Triethiodide is contraindicated in conditions like Renal impairment.
Effects
The severe or irreversible adverse effects of Gallamine Triethiodide, which give rise to further complications include Tachycardia in coronory artery disease patient.Gallamine Triethiodide produces potentially life-threatening effects which include Acute anaphylactic reactions. which are responsible for the discontinuation of Gallamine Triethiodide therapy.The symptomatic adverse reactions produced by Gallamine Triethiodide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diplopia, Respiratory depression, Ptosis, Increase in blood pressure, Weakness of face + neck muscle, Difficulty to swallow.
Indications
Gallamine Triethiodide is primarily indicated in conditions like Adjunct to anesthesia, Prophylaxis of NSAID-induced gastric and duodenal ulceration.
Interactions
No data regarding the interactions of Gallamine Triethiodide was found.
Interfrence
Risks
Drug should not be given to Cardiac / Hypertensive Patients, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store in a well closed container, . Protect from Sunlight.
Warnings
Use with caution in patients with hypertension or cardiac insufficiency when tachycardia would be undesirable; it should preferably be avoided in obstetric surgery. Gallamine should be administered by, or under the supervision of, an experienced anesthesiologist. Facilities for intubation, artificial respiration, and oxygen therapy should be available, as well as edrophonium or neostigmine and atropine as antidotes.
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