Estriol

Estriol is a naturally occuring oestrogen with actions and uses similar to those of oestradiol. Estriol is claimed to have a mild proliferative effect on endometrium. Estriol is used for menopausal hormone replacement therapy (HRT). Estriol is used intravaginally for the short-term treatment of menopausal atrophic vaginitis as acream or as pessaries.

Brands
OVESTIN
Adult Dose
Dose: 0.5 to 3 mg
Single Dose: 1.8 (1.75)
Frequency: 24 hourly
Route: PO
Instructions: For upto 1 month. Then 0.5-1.0 mg daily until restoration of epithelial integrity.
Neonatal
Paedriatic
Characteristics
Estriol also known as Oestriol. . It is of Semi Synthetic origin and belongs to Oestrone Sulphate. . The Molecular Weight of Estriol is 288.40. Its pKa is 13.62.
Contraindications
Estriol is contraindicated in conditions like Pregnancy,Breast feeding.
Effects
The symptomatic adverse reactions produced by Estriol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vomiting, Abdominal cramps, Breast enlargement, Weight changes, Sodium and fluid retention.
Indications
Estriol can be given in adjunctive therapy as an alternative drug of choice in Infertility, Vaginitis.
Interactions
No data regarding the interactions of Estriol was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Prolonged exposure to unopposed oestrogens may increase risk of developing endometrial cancer; migraine (or migraine like headaches); interrupt treatment periodicaally to assess need for continued treatment; diabetes (increased risk of heart disease); history of breast nodulesor fibrocystic disease; closely monitor breast status; risk factors for oestrogen-dependent tumours (e.g breast-cancer in first degree relative); uterine fibroids may increase in size, symptoms of endometriosis may be exacerbated; factors predisposing to thromboembolism; presence of phospholipid antibodies (increased risk of thrombotic events).
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