Verteporfin

A medicine that is activated by light. It has no direct effect but it works in presence of light and oxygen and produces its cell killing effect. It is used in photodynamic treatment of eye disorders involving abnormal growth of blood vessels in the back of the eye. It is activaetd by using a laser.

Brands
VISUDYNE
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. .
Contraindications
Verteporfin is contraindicated in conditions like Porphyria,Breast feeding.
Effects
The symptomatic adverse reactions produced by Verteporfin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Fever, Sweating, Blurred vision, Pruritus, Dysuria, SweatingX, Asthenia, Syncope, Hypersensitivity reactions, Chest pain, Backache, Hypercholesterolemia, Visual field defects, Rarely lacrimation disorders, Injection-site reactions including pain, edema, inflammation, hemorrahage, and discoloration, Changes in blood pressure and in heart rate, Flashing light.
Indications
Verteporfin is primarily indicated in conditions like Muscle relaxation (long duration) for surgery and intubation.
Interactions
No data regarding the interactions of Verteporfin was found.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
The drug causes temporary photosensitzation, and patients must avoid exposure of unprotected skin and eyes to bright light during infusion and 48 hors afterwards or bright indoor lights; hepatic impairment (avoid if severe), biliary obstruction; avoid extravasation; pregnancy (use only when potential benefit outweighs risk). Activation of the drug in the presence of oxygen generates free radicals, which cause vessel demage and subsequent platelet activation, thrombosis, and occlusion of choroidal neovascularization.
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