Clavulanic Acid

Clavulanic Acid is a β lactamase inhibitor. Clavulanic Acid is structurally related to the penicillins and used in combination with penicillin antibiotic to treat variety of bacterial infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Clavulanic Acid is important to take the drug for the full time period as prescribed. If you discontinue the therapy it may result in ineffective treatment.


Adult Dose
Dose: 125 mg
Single Dose: 120 (125)
Frequency: 12 hourly
Route: PO
Instructions: Only in combination with either Amoxicillin or Ticarcillin.
Neonatal
Dose: 6 mg/kg
Single Dose: 6 (6)
Frequency: 6 hourly
Route: Intramuscular
Instructions:
Paedriatic
Characteristics
cluvulanic acid is the derivative of Clavulanic Acid. It is of Semi Synthetic origin and belongs to Beta Lactam. It belongs to Beta Lactamase Inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Penicillin pharmacological group.The Molecular Weight of Clavulanic Acid is 199.20.
Contraindications
Clavulanic Acid is contraindicated in conditions like Glandular fever,Penicillin hypersensitivity.
Effects
The severe or irreversible adverse effects of Clavulanic Acid, which give rise to further complications include Hypersensitivity reactions, Eosinophilia, Severe diarrhea, Hepatic cholestasis.Clavulanic Acid produces potentially life-threatening effects which include Pseudomembranous colitis, Anaphylaxis. which are responsible for the discontinuation of Clavulanic Acid therapy.The signs and symptoms that are produced after the acute overdosage of Clavulanic Acid include Nausea, Vomiting.The symptomatic adverse reactions produced by Clavulanic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Fever, Maculopapular rash, Urticaria, Increase in serum transaminase.
Indications
Clavulanic Acid is primarily indicated in conditions like Bacterial infections, Myeloablative therapy followed by bone marrow transplantation, Respiratory tract infections, Urinary tract infection.
Interactions
No data regarding the interactions of Clavulanic Acid was found.
Interfrence
Glucose Test
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted susp) Store in refrigerator. Use within 10 days if kept at room temperature. Tab, Oral Susp, Dry Powder for Inj Store at room temperature, Below 25°C. Protect from Moisture.
Warnings
Clavulanic acid should be used with caution in patients with other illnesses or any allergy especially to penicillin or other antibiotics. This medication should be used only if clearly needed during pregnancy or lactation.
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