Mafenide Acetate

Mafenide Acetate is an antibacterial, belongs to sulphonamides. Mafenide Acetate is used topically to prevent bacterial colonisation and infection of burn wounds. Mefenide acetate is absorbed from burn sites, and systemic levels are produced. The drug and its metabolites cause metabolic acidosis, a side effect that limits its usefulness.

Brands
Adult Dose
Dose: 1.5 mm
Single Dose: 1.5 (1.5)
Frequency: 12 hourly
Route: Topical
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Sulfonamides. . The Molecular Weight of Mafenide Acetate is 246.28.
Contraindications
Mafenide Acetate is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
Mafenide Acetate produces potentially life-threatening effects which include Hynolytic Anaemia. which are responsible for the discontinuation of Mafenide Acetate therapy.The symptomatic adverse reactions produced by Mafenide Acetate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Allergic reactions, Hyperventilation, Metabolic acidosis, Urinary alkalosis, Intense pain at sites of application, Loss of fluid by evaporation from the burn surface.
Indications
Mafenide Acetate is primarily indicated in conditions like Bacterial infections, Burns.
Interactions
No data regarding the interactions of Mafenide Acetate was found.
Interfrence
None well documented
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Since occlusive dressings are not used. The drug and its primary metabolite inhibit Carbonis Anhydrase, and the urine becomes alkaline.A metabolic acidosis with compensatory tachypnea and hyperventilation may ensue and has limited the usefulness of mafenide.
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