Disodium Pamidronate

Disodium Pamidronate is a bisphosphonate, inhibits bone resorption and thus reduces bone turn over. Disodium Pamidronate is used in the treatment of bone disorders in which excessive bone resorption is a problem, such as paget`s disease of bone and osteoporosis. Disodium Pamidronate is also used as an adjunct insevere hypercalcaemic conditions especially associated with malignancies.

Brands
Adult Dose
Dose: 30 mg
Single Dose: 30 (30)
Frequency: 24 hourly
Route: IV
Instructions: For paget disease: administered as a 4-hour infusion on 3 consecutive days for a total dose of 90 mg.
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Disodium Pamidronate is 369.00.
Contraindications
Disodium Pamidronate is contraindicated in conditions like Pregnancy,Breast feeding.
Effects
The symptomatic adverse reactions produced by Disodium Pamidronate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Anorexia, Diarrhea, Fever, Myalgia, Constipation, Insomnia, Abdominal pain, Rashes, Confusion, Pruritus, Lethargy, Hallucination, Dyspepsia, Malaise, Hypotension, Somnolence, Flushing, Arthralgia, Nausea and vomiting, Muscle cramps, Influenza like syndrome, Agitation, Conjunctivitis, Rigors, Seizures, Transient rise in body temperature, Transient bone pain, Local reaction at injection site, Confusion, dizziness, dyspepsia, Thrombophili.
Indications
'Disodium Pamidronate is primarily indicated in conditions like Hypercalcaemia due to malignancy, Hypercalcaemia of malignancy, Osteolytic bone metastases, Osteolytic lesions and bone pain, Paget''s disease of bone, Sedation with amnesia.'
Interactions
No data regarding the interactions of Disodium Pamidronate was found.
Interfrence
Abnormal LFTs
Risks
Drug should not be given to Paediatrics, and Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Disodium Pamidronate should be used with caution in patients with cardiac desease with renal impairment---monitor renal function in renal disease or predisposition to renal impairment (e.g in multiple myeloma or tumor induced hypercalcaemia); cardiac disease (especially in elderly); previous thyroid surgery (risk of hypocalcaemia); monitor serum electrolyte, calcium and phosphate---possibility of convulsions due to electrolyte changes; avoid concurrent use with other bisphosphonate. DRIVING: Patients should be warned against driving or operating machinery immediately after treatment (somnolence or dizziness may occur)
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