Cinoxacin

Cinoxacin is an antibacterial quinolone. Cinoxacin is similar in structure and function to nalidixic acid. Because of its relatively weak antibacterial activity, it was useful only for the treatment of urinary tract infections. Cinoxacin is rarely used now, have been made obsolete by the more efficacious flourinated quinolones.

Brands
Adult Dose
Dose: 7.412 mg/kg
Single Dose: 7.4 (7.412)
Frequency: 12 hourly
Route: PO
Instructions: -
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Cinoxacin also known as Azolinic Acid. . It is of Synthetic origin and belongs to Naphthyridine. It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Cinoxacin is 262.00. Its pKa is 4.7.
Contraindications
Cinoxacin is contraindicated in conditions like Hypersensitivity,Renal impairment.
Effects
The severe or irreversible adverse effects of Cinoxacin, which give rise to further complications include Epidermal necrolysis, Epidermal necrolysis.Cinoxacin produces potentially life-threatening effects which include Anaphylactoid reactions. which are responsible for the discontinuation of Cinoxacin therapy.The symptomatic adverse reactions produced by Cinoxacin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Diarrhea, Nervousness, Tinnitus, Skin rashes, Confusion, Elevation of liver enzymes, Raised serum creatinine, Increased intracranial pressure, Raised blood urea nitrogen, Hepatic damage, Confusion, nervousness, Nervousness, Skin rashes, dizziness, Tendon damage.
Indications
Cinoxacin is primarily indicated in conditions like Cystitis, Pyelitis, Pyelonephritis, Urinary tract infection.
Interactions
No data regarding the interactions of Cinoxacin was found.
Interfrence
Reduction methodFalse + Result in urinary glucose tests using copper reduction method
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Cinoxacin should be used with caution in patients with pre-existing kidney or liver disease or any allergy especially to antibiotics. This drug should be used only if clearly needed during pregnancy or lactation.
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