Sertindole

Sertindole is an antipsychotic drug that is an antagonist at central dopamine, serotonin, and adrenergic receptors. It was used in the treatment of schizophrenia, but its marketing was suspended due to cardiac arryhthmias and cardiac deaths associated with its use.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. .
Contraindications
Sertindole is contraindicated in conditions like Pregnancy,Breast feeding,Treatment of pulmonary embolism.
Effects
The symptomatic adverse reactions produced by Sertindole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Dyspnea, Dry mouth, Postural hypotension, Rhinitis, Paresthesias, Extra pyramidal symptoms, Seizures, Abnormal ejaculation.
Indications
Sertindole is primarily indicated in conditions like Schizophrenia.
Interactions
Sertindole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholSertindole has the potential of causing drowsiness, thus in combination Alcohol sedation may result. AmprenavirAmprenavir increases plasma concentration of Sertindole; increased risk of ventricular arrhythmias. ADICE: Avoid concomitant use.MajorBromazepamSertindole has the potential of causing drowsiness, thus in combination Bromazepam sedation may result. DiazepamSertindole has the potential of causing drowsiness, thus in combination Diazepam sedation may result. PhenobarbitoneSertindole has the potential of causing drowsiness, thus in combination Phenobarbitone sedation may result. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store in a well closed container, . Protect from Sunlight, Moisture and Heat.
Warnings
Sertindole should be used with caution in patients with hepatic impairmen (slower titration and lower maintenance dose in mild to moderate hepatic impairment; avoid in severe); diabetes;correct hypokalaemia or hypomagnesaemia before treatment. Caution is also required in patients with cardiovascular disease, monitor blood pressure during dose titration and early maintenance therapy (risk of postural hypotension); history of epilepsy; it should be used with caution in the elderly. DRIVING: Drowsiness may affect performance of skilled tasks (e.g driving or operating machinery), especially at start of treatment; effects of alcohol are enhanced. WITHDRAWL: Withdrawl of antipsychotic drugs after long-term therapy should always be gradual and closely monitored to avoid the risk of acute withdrawl syndrome or rapid relapse.
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