Butobarbital

Butobarbital is a barbiturate with general properties similar to amylobarbital. Butobarbital is now rarely used due to associated risk of adverse effects and dependence.


Brands
Adult Dose
Dose: 15 to 30 mg
Single Dose: 22 (22.5)
Frequency: 8 hourly
Route: PO
Instructions: Dose for sedation maintenance (routine daytime sedation), to relieve anxiety, tension or apprehension.
Neonatal
Paedriatic
Characteristics
Butobarbital also known as Butobarbitone, Butobarbitone. . It is of Synthetic origin and belongs to Barbiturates. . The Molecular Weight of Butobarbital is 212.20.
Contraindications
Butobarbital is contraindicated in conditions like Pregnancy,Porphyria,Breast feeding,Heterozygous familial hypercholesterolaemia,Hyperlipidaemias, see instruction,Central retinal venous/arterial thrombosis.
Effects
The symptomatic adverse reactions produced by Butobarbital are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Respiratory depression, Hypersensitivity reactions, Hangover with drowsiness, Paradoxical excitement, Precede sleep.
Indications
Butobarbital is primarily indicated in conditions like Hypnotic, Sedative, and can also be given in adjunctive therapy as an alternative drug of choice in Cerebrovascular disease, Epilepsy.
Interactions
Butobarbital is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementVORICONAZOLEButabarbital may reduce serum concentrations and efficacy of voriconazole. Concomitant voriconazole and long-acting barbiturates therapy is contraindicated These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tabs Store in a well closed container, at room temperature, . Protect from Sunlight, Moisture and Heat.
Warnings
Avoid use where possible; dependence and tolerance readily occur,abrupt withdrawl may precipitate serious withdrawl syndrome (rebound insomnia ,anxiety, tremor, dizziness, nausea, convulsions, delirium, and death), repeated doses are cumulative and may lead to excessive sedation, respiratory disease, renal disease, hepatic impairment. DRIVING: Drowsiness may persist the next day and affect performance of the skilled tasks (e.g driving); effects of alcohol enhanced.
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